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This book is the first to provide balanced examination of both pediatric liver disease and liver transplantation – two topics that are inherently related, given that most chronic liver disorders eventually require organ replacement. The different forms of liver disease encountered in the pediatric age group are first discussed in a series of disease-specific chapters that have a reader-friendly, uniform structure covering pathophysiology, diagnostic and treatment algorithms, clinical cases, and transition to adult care. Key topics in the field of liver transplantation are then addressed. Examples include indications and contraindications, surgical techniques and complications, immunosuppre...
The induction of antigen-specific immune responses after in vivo transfection with expression plasmids has triggered a revolution of vaccine research. After a first hype, evoked by the fascinating options of this method, clinical studies did not reach the ambitious aims and a phase of disillusion ensued. It became obvious that Gene vaccines displayed a weaker immunogenicity in humans than had been observed in the mouse models. Meanwhile these hurdles have been overcome and gene vaccines undergo a renaissance. The present book gives an update of the “world of naked gene vaccines”, namely DNA and RNA vaccines. Its content ranges from general mechanisms, inherent immunostimulatory properties and the vast potential to modulate immune responses, to recent successful clinical studies and approved veterinary gene vaccines. Beyond the state-of-the-art of genetic immunization, the reader will be stimulated with a chapter addressing “burning questions”.
Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging...
The publication of the extensive 7-volume work Comprehensive Molecular Insect Science provided library customers and their end-users with a complete reference encompassing important developments and achievements in modern insect science, including reviews on the ecdysone receptor, lipocalins, and bacterial toxins. One of the most popular areas in entomology is control, and this derivative work, Insect Control, taps into a previously unapproached market – the end user who desires to purchase a comprehensive yet affordable work on important aspects of this topic. Contents will include timeless articles covering insect growth- and development-disrupting insecticides, mechanisms and use of Bac...
This edition of this comprehensive reference combines a strong scientific base with a clinical focus to address the principal disorders of bone and mineral metabolism, including osteoporosis, kidney stone formation, abnormal serum mineral levels, Paget's disease, and other conditions. The contributors examine normal bone structure and mineral metabolism throughout the life cycle, explain the mechanisms underlying each disorder, and provide succinct guidance on evaluation and management.
The bacterial wilt diseases caused by members of the Ralstonia solanacearum species complex have never been more important. The research presented in this volume reveals a pathogen on the move, with a growing global profile. While these diseases inflict ongoing and increasing crop losses on subsistence farmers, the pathogen now has significant political and economic impact in the developed world.This book, based on the 3rd International Bacterial Wilt Symposium, covers topics ranging from the basic biology of the host-pathogen interaction to applied research, designed to immediately address disease losses in the field. Contributors to the book span a broad range of applied and basic biologis...
Stockley's Drug Interactions, edited by Karen Baxter, remains the world's most comprehensive and authoritative reference book on drug interactions. It provides the busy healthcare professional with quick and easy access to clinically relevant, evaluated and evidence-based information on drug interactions.
Leaping Ahead: Advances in Prosimian Biology presents a summary of the state of prosimian biology as we move into the second decade of the 21st century. The book covers a wide range of topics, from assessments of diversity and evolutionary scenarios, through ecophysiology, cognition, behavioral and sensory ecology, to the conservation and survival prospects of this extraordinary and diverse group of mammals. The collection was inspired by an international conference in Ithala, KwaZulu-Natal, South Africa in 2007, where prosimian biologists gathered from Canada, Finland, France, Germany, India, Italy, Japan, Madagascar, South Africa, Tanzania, the United Kingdom, and the United States of Amer...