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DNA replication in eukaryotes is an important field, particular ly because of its direct impact on the study of cancer. The under standing of molecular mechanisms of replication and their regulation should allow a better comprehension of the alterations that lead to the proliferation of tumor cells and to error-prone repair in cells exposed to radiation or chemical carcinogens. During the last several years, many enzymes and proteins which participate in replication of DNA in eukaryotic cells have been identified, isolated and characterized. New concepts in chromatin structure have refocused attention on the study of replication of DNA complexed with his tones and non-histone chromosomal pro...
DNA replication is a fundamental part of the life cycle of all organisms. Not surprisingly many aspects of this process display profound conservation across organisms in all domains of life. The chapters in this volume outline and review the current state of knowledge on several key aspects of the DNA replication process. This is a critical process in both normal growth and development and in relation to a broad variety of pathological conditions including cancer. The reader will be provided with new insights into the initiation, regulation, and progression of DNA replication as well as a collection of thought provoking questions and summaries to direct future investigations.
The existence of life at high temperatures is quiet fascinating. At elevated temperatures, only microorganisms are capable of growth and survival. Many thermophilic microbial genera have been isolated from man-made (washing machines, factory effluents, waste streams and acid mine effluents) and natural (volcanic areas, geothermal areas, terrestrial hot springs, submarine hydrothermal vents, geothermally heated oil reserves and oil wells, sun-heated litter and soils/sediments) thermal habitats throughout the world. Both culture-dependent and culture-independent approaches have been employed for understanding the diversity of microbes in hot environments. Interest in their diversity, ecology, ...
The 4-volume Encyclopedia of Biological Chemistry, Second Edition, represents the current state of a dynamic and crucial field of study. The Encyclopedia pulls together over 500 articles that help define and explore contemporary biochemistry, with content experts carefully chosen by the Editorial Board to assure both breadth and depth in its coverage. Editors-In-Chief William J. Lennarz and M. Daniel Lane have crafted a work that proceeds from the acknowledgement that understanding every living process-from physiology, to immunology, and genetics-is impossible without a grasp on the basic chemistry that provides its underpinning. Each article in the work provides an up-to-date snapshot of a ...
Snow and Ice-Related Hazards, Risks, and Disasters provides you with the latest scientific developments in glacier surges and melting, ice shelf collapses, paleo-climate reconstruction, sea level rise, climate change implications, causality, impacts, preparedness, and mitigation. It takes a geo-scientific approach to the topic while also covering current thinking about directly related social scientific issues that can adversely affect ecosystems and global economies. Puts the contributions from expert oceanographers, geologists, geophysicists, environmental scientists, and climatologists selected by a world-renowned editorial board in your hands Presents the latest research on causality, glacial surges, ice-shelf collapses, sea level rise, climate change implications, and more Numerous tables, maps, diagrams, illustrations and photographs of hazardous processes will be included Features new insights into the implications of climate change on increased melting, collapsing, flooding, methane emissions, and sea level rise
Human Molecular Genetics is an established and class-proven textbook for upper-level undergraduates and graduate students which provides an authoritative and integrated approach to the molecular aspects of human genetics. While maintaining the hallmark features of previous editions, the Fourth Edition has been completely updated. It includes new Key Concepts at the beginning of each chapter and annotated further reading at the conclusion of each chapter, to help readers navigate the wealth of information in this subject. The text has been restructured so genomic technologies are integrated throughout, and next generation sequencing is included. Genetic testing, screening, approaches to therapy, personalized medicine, and disease models have been brought together in one section. Coverage of cell biology including stem cells and cell therapy, studying gene function and structure, comparative genomics, model organisms, noncoding RNAs and their functions, and epigenetics have all been expanded.
In this third edition of his popular undergraduate-level textbook, Des Nicholl recognises that a sound grasp of basic principles is vital in any introduction to genetic engineering. Therefore, the book retains its focus on the fundamental principles used in gene manipulation. It is divided into three sections: Part I provides an introduction to the relevant basic molecular biology; Part II, the methods used to manipulate genes; and Part III, applications of the technology. There is a new chapter devoted to the emerging importance of bioinformatics as a distinct discipline. Other additional features include text boxes, which highlight important aspects of topics discussed, and chapter summaries, which include aims and learning outcomes. These, along with key word listings, concept maps and a glossary, will enable students to tailor their study to suit their own learning styles and ultimately gain a firm grasp of a subject that students traditionally find difficult.