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Novel Agents for Multiple Myeloma
Multiple myeloma (MM) is a malignant neoplasm of plasma cells that accumulate in bone marrow, leading to bone destruction and marrow failure. It accounts for approximately 1.8% of all hematologic and solid cancers and slightly > 15% of hematologic malignancies in the United States. MM is typically sensitive to different classes of cytotoxic drugs, both as frontline treatment and as treatment for relapsed disease. Unfortunately, even if responses are typically durable, nowadays MM is not considered curable with current approaches. However, MM survival rates have been brilliantly improved thanks to the introduction of novel agents: patients diagnosed after 2010 have had higher rates of novel therapy use and better survival outcomes compared with those of earlier years. Most relevant therapeutic advances over the past decades has been the introduction of novel therapies, such as immune-modifying agents (thalidomide and lenalidomide) and proteasome inhibitors (bortezomib), adopted with or without stem cell transplantation.
Myeloma Bone Disease
This book presents the forefront in the science and clinical management of myeloma bone disease. Coverage begins with sections on clinical presentation, imaging, and biochemical markers and goes on to discuss radiation, surgical, and medical therapies.
The Great Vogue for the Guitar in Western Europe
The first book devoted to the composers, instrument makers and amateur players who advanced the great guitar vouge throughout Western Europe during the early decades of the nineteenth century.Contemporary critics viewed the fashion for the guitar with sheer hostility, seeing in it a rejection of true musical value. After all, such trends advanced against the grain of mainstream musical developments of ground-breaking (often Austro-German) repertoire for standard instruments. Yet amateur musicians throughout Europe persisted; many instruments were built to meet the demand, a substantial volume of music was published for amateurs to play, and soloist-composers moved freely between European cit...
Management of Bone Disease and Kidney Failure in Multiple Myeloma
This pocket guide provides a concise yet comprehensive overview of the two most prominent clinical features of multiple myeloma (MM), bone disease and renal failure. The first half of the text reviews critical aspects of bone disease in MM, including pathophysiology, the use of imaging modalities and drugs in treatment, and the role of orthopedic surgery. The latter half of the book reviews major components of kidney disease in MM, from pathophysiology to treatment. Written by experts in the field, Management of Bone Disease and Kidney Failure in Multiple Myeloma: A Pocket Guide is a valuable resource for clinicians and practitioners who manage patients afflicted with multiple myeloma.
Galectins in Cancer and Translational Medicine
In the post-genomic era, many efforts have been devoted to better understanding the biological information encoded by the cell "glycome" in normal and pathologic conditions. The glycan signature of human cells plays a pivotal role in regulating fundamental biological processes, which are critical for cell physiology and for cancer as well. Galectins (also worded S-type lectins) are an evolutionarily conserved family of endogenous lectins, which bind carbohydrates with high specificity. These molecules, which can be found both intracellularly and in the extracellular milieu, are functionally active in converting glycan-containing information into cell biological programs. This fashionable mec...
Brain Informatics and Health
This book constitutes the proceedings of the International Conference on Brain Informatics and Health, BIH 2014, held in Warsaw, Poland, in August 2014, as part of 2014 Web Intelligence Congress, WIC 2014. The 29 full papers presented together with 23 special session papers were carefully reviewed and selected from 101 submissions. The papers are organized in topical sections on brain understanding; cognitive modelling; brain data analytics; health data analytics; brain informatics and data management; semantic aspects of biomedical analytics; healthcare technologies and systems; analysis of complex medical data; understanding of information processing in brain; neuroimaging data processing strategies; advanced methods of interactive data mining for personalized medicine.
A quiet provincial town
A violent explosion during the inauguration party of Villa Brandi, an eighteenth-century villa restored thanks to the financial contribution from a well-known international football coach, causes four people to lose their life with a fifth seriously injured. Caterina Ruggeri, head of the local Homicide Division, who is present at the party with her partner and has escaped unhurt from the attack, will immediately take the reins of the investigation. Her work however is misled by obscure characters linked on one hand to the local Freemasonry and on the other to the Secret Services. Our detective will have to overcome many obstacles to arrive at the truth, which has its roots in the mists of ti...
Beyond Fingal's Cave
Demonstrates the profound impact of The Poems of Ossian on composers of the Romantic Era and later: Beethoven, Schubert, Mendelssohn, Brahms, Massenet, and many others. Beyond Fingal's Cave: Ossian in the Musical Imagination is the first study in English of musical compositions inspired by the poems published in the 1760s and attributed to a purported ancient Scottish bard named Ossian. From around 1780 onwards, the poems stimulated poets, artists, and composers in Europe as well as North America to break away from the formality of the Enlightenment. The admiration for Ossian's poems -shared by Napoleon, Goethe, and Thomas Jefferson - was an important stimulus in the development of Romantici...
