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Distils the most valuable discoveries in dementia research into clear, insightful chapters written by international experts.
This book introduces the companion modelling approach by presenting the stance that underpins it, the methods and tools used with stakeholders and the specific role of models during the process. It addresses the means to deal with the different levels of decision-making and to take into account the various power relationships. It proposes a methodology to assess the impact of the approach on the stakeholders involved in the process. The book includes 27 case studies and 7 teaching tools that describe the successful use of the approach in a variety of settings or teaching contexts. It is intended for researchers working on rural development or renewable resources management, as well as students and teachers.
Climate is a paradigm of a complex system. Analysing climate data is an exciting challenge, which is increased by non-normal distributional shape, serial dependence, uneven spacing and timescale uncertainties. This book presents bootstrap resampling as a computing-intensive method able to meet the challenge. It shows the bootstrap to perform reliably in the most important statistical estimation techniques: regression, spectral analysis, extreme values and correlation. This book is written for climatologists and applied statisticians. It explains step by step the bootstrap algorithms (including novel adaptions) and methods for confidence interval construction. It tests the accuracy of the algorithms by means of Monte Carlo experiments. It analyses a large array of climate time series, giving a detailed account on the data and the associated climatological questions. This makes the book self-contained for graduate students and researchers.
Tissue-resident memory T (TRM) cells play a major role in control of viral infections. Their involvement in cancer diseases has been more recently demonstrated. This non-circulating T-lymphocyte subset lacks molecules enabling egress from the tissue and migration to lymph nodes, expresses specific markers of residency and displays specific transcription factors. The present special issue elucidates our current knowledge on CD8+ TRM cells and explores less frequently described resident subsets, such as CD4+ TRM and innate-like cells, as well as their specific metabolism and niches for their formation in infectious and cancer diseases.
Agroforestry -- the practice of integrating trees and other large woody perennials on farms and throughout the agricultural landscape -- is increasingly recognized as a useful and promising strategy that diversifies production for greater social, economic, and environmental benefits. Agroforestry and BiodiversityConservation in Tropical Landscapes brings together 46 scientists and practitioners from 13 countries with decades of field experience in tropical regions to explore how agroforestry practices can help promote biodiversity conservation in human-dominated landscapes, to synthesize the current state of knowledge in the field, and to identify areas where further research is needed. Agro...
This volume covers the latest methods used in clinical neurochemistry laboratories for both clinical practice and research. Chapters in this book discuss topics such as techniques for cerebrospinal fluid (CSF) collection, pre-analytical processing, and basic CSF analysis; an examination of biomarkers including ELISA and automated immunochemical assays for amyloid and tau markers for Alzheimer’s disease; the analysis of neurofilaments by digital ELISA; and an example of successful novel immunoassay development. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and thorough, Cerebrospinal Fluid Biomarkers is a valuable resource for clinicians and researchers to use in CSF labs and CSF courses.
This volume presents cutting-edge thinking & research on linkages among SES, parenting & child development. The authors represent an array of different disciplines, & they approach the issues of SES parenting & child dev. from a variety of perspectives.