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Numerous genetic methods can be utilised to link a phenotype to a single molecular target but annotated small molecule chemical probes and even entire chemogenomic libraries are increasingly being used as a complementary approach. This book will comprehensively cover the state of the art in chemical probes and best practice for use in target discovery, illustrated throughout with examples. Ideal for students and established biochemists, the book will also cover new technologies for probe discovery, new probe modalities, the new field of probes for RNA targets and the mature field of kinase chemical probes.
"The Fourth "R"" by George O. Smith. Published by Good Press. Good Press publishes a wide range of titles that encompasses every genre. From well-known classics & literary fiction and non-fiction to forgotten−or yet undiscovered gems−of world literature, we issue the books that need to be read. Each Good Press edition has been meticulously edited and formatted to boost readability for all e-readers and devices. Our goal is to produce eBooks that are user-friendly and accessible to everyone in a high-quality digital format.
Hellenistic astrology is a tradition of horoscopic astrology that was practiced in the Mediterranean region from approximately the first century BCE until the seventh century CE. It is the source of many of the modern traditions of astrology that still flourish around the world today, although it is only recently that many of the surviving texts of this tradition have become available again for astrologers to study. Hellenistic Astrology: The Study of Fate and Fortune is one of the first comprehensive surveys of this tradition in modern times. The book covers the history, philosophy, and techniques of ancient astrology, with a special focus on demonstrating how many of the fundamental concepts underlying the practice of western astrology originated during the Hellenistic period.
Written by National Board Public Affairs Director of the National Board of Boiler and Pressure Vessel Inspectors Paul Brennan. the book connects the dots between industrial-size pressure vessels and common pressure-retaining items the public uses every day. Through compelling short stories, essays, illustrations, and rare photos, Blowback details the danger that exist when pressure equipment is misused, neglected, or defective."--Publisher description.
"Paul Hirsch's revelatory book opens the archives to show the complex relationships between comic books and American foreign relations in the mid-twentieth century. Scourged and repressed on the one hand, yet co-opted and deployed as propaganda on the other, violent, sexist comic books were both vital expressions of American freedom and upsetting depictions of the American id. Hirsch draws on previously classified material and newly available personal records to weave together the perspectives of government officials, comic-book publishers and creators, and people in other countries who found themselves on the receiving end of American culture"--
Welcome to Black Cat Weekly #37. Another hefty issue is in hand, featuring novels and novellas by some of the greats of the mystery and science fiction fields. And, as expected, our acquiring editors have found some true gems. Michael Bracken has selected an original suspense tale from from N. M. Cedeño, Barb Goffman has a mystery from the always-superb Janice Law, and Cynthia Ward has Naomi Kritzer’s “Evil Opposite”—a great alternate-universe tale (and our featured story this issue). Of course, there’s lots more—including a tale of the Mounties by Hulbert Footner, a historical adventure from Otis Adelbert Kline, a detective novel featuring Nick Carter, and science fiction and f...
George O. Smith's 'Ultimate SF Collection' is a fantastic anthology that showcases the author's incredible talent for writing science fiction. The collection consists of a series of short stories that explore various themes such as space exploration, artificial intelligence, and the future of humanity. Smith's writing style is characterized by its attention to scientific detail and its ability to create immersive worlds that captivate the reader. His stories are not only entertaining but also provoke thought about the possibilities of the future. Set against the backdrop of the Golden Age of science fiction, Smith's work is a shining example of the genre at its best. George O. Smith was a pr...
Boldly signifying the cultural issues of the 1960s and 1970s in groundbreaking pieces such as Grey Gardens, Gimme Shelter, and Showman, filmmakers and brothers David and Albert Maysles used an approach to documentary film that involved spontaneous observation of naturally occurring events. With no rehearsed footage and no preconceived plots, their revolutionary work eschewed the authoritative voice-over narrator, didactic scripts, and the traditional problem-and-solution format used by the majority of their predecessors in the genre and duly influenced subsequent directors in both fiction and nonfiction film. Their collaboration from 1962 until David’s death in 1987 wrought thirteen major ...