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A guide to techniques for the discovery and evaluation of pharamcologically active compounds for therapeutic development, this book covers rational drug design, high-throughput screening, and genetic approaches to drug discovery. The authors focus on advances in the use of combinatorial chemistry and natural products, both of which support the chemical diversity for many drug screening programmes. They examine typical screening studies and their link to robotics and informatics in detail and present an overview of current progress within anitsense therapeutics. The book explores the rapid changes in drug discovery resulting from developments in molecular biology, robotics, and informatics.
Not since the late 1970s has a single work presented the biology of this heterogenous group of secondary alkaloids in such depth. Alkaloids, a unique treatise featuring leaders in the field, presents both the historical use of alkaloids and the latest discoveries in the biochemistry of alkaloid production in plants alkaloid ecology, including marine invertebrates, animal and plant parasites, and alkaloids as antimicrobial and current medicinal use . Highlights include chapters on the chemical ecology of alkaloids in host-predator interactions, and on the compartmentation of alkaloids synthesis, transport, and storage. Extensive cross-referencing in tabular format makes this volume an excellent reference.
Chemistry and Biology is a celebration of the outstanding contributions to the field by Professor R.H.F. Manske, who founded the series in 1950. This special volume demonstrates the dramatic changes in alkaloidchemistry since then. It also offers a unique overview of recent developments in major areas of alkaloid chemistry and biology and looks at how these areas will develop in the future. These fourteen contributions are written by many of the leading alkaloid chemists in the world, and thus comprise a unique view of alkaloids and their contributions to the health and well-being of humankind. - Indispensable reference work written by leading experts in the field - Provides up-to-date, timely reviews on compounds and classes of great interest - Covers synthesis, biosynthesis, biology, as well as isolation and structure elucidation - An essential research tool for anyone working with alkaloids from a chemical or biological perspective
People have long used wild plants as food and medicine, and for a myriad of other important cultural applications. While these plants and the foraging activities associated with them have been dismissed by some observers as secondary or supplementaryÑor even backwardÑtheir contributions to human survival and well-being are more significant than is often realized. Eating on the Wild Side spans the history of human-plant interactions to examine how wild plants are used to meet medicinal, nutritional, and other human needs. Drawing on nonhuman primate studies, evidence from prehistoric human populations, and field research among contemporary peoples practicing a range of subsistence strategie...
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Volume 7 of Alkaloids: Chemical and Biological Perspectives appears under the aegis of a new publisher: the distinguished firm of Springer Verlag New York, Inc. This volume presents three timely reviews on alkaloids: Chapter 1 reviews the homoerythrina and related alkaloids. a group of compounds occurring in seventeen species that are native to countries bordering the western Pacific. Since the last review in 1981, the number of these alkaloids has doubled. Chapter 2 is a comprehensive review of the carbon-13 NMR spectros copy of steroidal alkaloids. Because more than 350 plant species have yielded steroidal alkaloids and these alkaloids exhibit a wide spectrum of biological activities, incl...
Colobine monkeys have a unique digestive system, analagous to that of ruminants, which allows them to exploit foliage as a food source. This gives them a niche in Old World forests where they are often the only abundant medium-sized arboreal folivorous mammal. From a possible Miocene origin, Colobine monkeys have radiated into a wide variety of forms inhabiting a range of tropical woodlands in Africa and Asia. Most of the extant species have been subject to long term field studies, but until this book, no synthesis of work on this group has been available. The central theme of is that of adaptive radiation, showing how the special features of colobine anatomy interacted with a range of ecosystems to produce the distinctive species of today. The book discusses parallels with other mammalian groups, and will be of relevance to workers in evolutionary ecology, primatology and tropical ecology.
Volume 11 of this series presents five timely reviews on current research on alkaloids. Chapter 1 by Paul L. Schiff, Jr. is a monumental survey of research that has been carried out over the past decade on the Thalictrum alkaloids. Forty-six new alkaloids are described from fifteen species of the genus Thalictrum, as well as 116 alkaloids of known structure from thirty-six species and subspecies of the genus. The chapter includes discussions of isolation and structure elucidation, analysis, biosynthesis, cell culture, and pharmacology. Also featured are inclusive compilations of botanical sources, alkaloids by alkaloid types, and calculated molecular weights of the Thalictrum alkaloids.Chapt...