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In this masterful account, a historian of science surveys the molecular biology revolution, its origin and continuing impact. Since the 1930s, a molecular vision has been transforming biology. Michel Morange provides an incisive and overarching history of this transformation, from the early attempts to explain organisms by the structure of their chemical components, to the birth and consolidation of genetics, to the latest technologies and discoveries enabled by the new science of life. Morange revisits A History of Molecular Biology and offers new insights from the past twenty years into his analysis. The Black Box of Biology shows that what led to the incredible transformation of biology w...
Contributors. -- Preface. -- C. Seidman, Introduction. -- I. Origins and Early Morphogenesis: -- P.P.L. Tam and G.C. Schoenwolf, Cardiac Fate Maps: Lineage Allocation, Morphogenetic Movement, and Cell Commitment. -- T. Mikawa, Cardiac Lineages. -- II. Cardiac Induction: -- T.J. Mohun and L.M. Leong, Heart Formation and the Heart Field in Amphibian Embryos. -- T.M. Schultheiss and A.B. Lassar, Vertebrate Heart Induction. -- III. Genetic Dissection of Heart Development: -- R. Bodmer and M. Frasch, Genetic Determination in Drosophilia Heart Development. -- J. Alexander and D.Y.R. Stainier, Mutations Affecting Cardiac Development in Zebrafish. -- R.P. Harvey, C. Biben, and D.A. Elliott, Transcriptional Control and Pattern Formation in the Developing Vertebrate Heart: Studies on NK-2 Class Homeodomain Factors. -- B.L. Black and E.N. Olson, Control of Cardiac Development by the Family of MEF2 Transcription Factors. -- D. Srivastava, Segmental Regulation of Cardiac Development by the Basic He ...
This book explores craniofacial anatomical variations using photographic images, three-dimensional images, and computed tomography reconstruction, giving the reader a better understanding of the craniofacial structures involved in each type of facial cleft, their phenotypic variations, and their associations with other rare facial clefts. This will also aid the visualization of the relationship between tissue and bone changes. This book, through providing in-depth knowledge of the morphology of rare facial clefts, aims to contribute towards the establishment of personalized and individualized therapeutic practices in highly complex cases of facial clefts, and the improvement of the rehabilitation process for the patients.
In this book, the clinical chapters are organized into sections by defined developmental pathways or gene families, and each section is preceded by a general overview. For each disorder the authors cover the disease-causing genes, the role of these genes in development as elucidated in model organisms, the human mutations that have been identified, and the developmental pathogenesis of the condition. Clinical descriptions, along with discussions of therapy and counseling, are provided. This book will be an invaluable resource for physicians, dentists, and other health professionals and for basic scientists interested in developmental processes and genetic perturbations that affect them.
Extraordinary advances have been made in the field of human molecular genetics during the past five years. The ability to amplify a specific region ofDNA a millionfold in a few hours using the polymerase chain reaction has led to the rapid identification of mutations in human disease and of DNA sequence polymorphisms on every human chro- some. DNA fragments of up to 1 megabase in length can now be resolved by pulsed-field gel electrophoresis to create long-range physical maps of important regions of the genome, and can be cloned in the form of yeast artificial chromosomes. The discovery of highly variable "minisatellite" DNA sequences has led to the development of DNA fingerprinting. The app...
Preceded by: Inborn errors of development / edited by Charles J. Epstein, Robert P. Erickson, Anthony Wynshaw-Boris. 2nd ed. 2008.
The first edition of Embryos, Genes and BirthDefects, edited by the late Peter Thorogood, was a radicalnew book aimed at bridging the gap between the medical disciplinesof embryology and dysmorphology, and recent advances in cellular,molecular and developmental biology. This new edition remainsunique in its breadth and brings up to date our understanding ofbirth defects and of the strategies utilized to gain suchknowledge. It features new chapters on human cytogenetics,mutagenesis and the eyes and ears. The book presents key topics in developmental biology andexplains how they provide the foundations for understandingclinical birth defects. The first six chapters introduce conceptsand strate...
Embryos, Genes and Birth Defects is a radical new book that bridges the gap between the medical disciplines of embryology and dysmorphology, with current advances in cell, molecular and developmental biology research. Written primarily for paediatricians, obstetricians, clinical geneticists and allied workers, this book introduces cell and developmental biology concepts, and guides the reader through the recent progress modern molecular biology has made to our understanding of human development. Developmental and cellular biologists will also learn how errors in the cellular and genetic mechanisms can lead to classical disorders diseases and syndromes.
It is difficult to think of an example of an advancement in the biological sciences that has had an impact on society similar to that of the new genetics. Recent developments in biotechnology have occasioned much discussion among academics, professionals, and lay people alike. In particular, many questions and concerns have arisen over the acquisi tion, access, and control of genetic information. There are several reasons why the new genetics has commanded such widespread attention, and why it is now the subject of con siderable debate. Special reference is given in this volume to the implications of genetic information for five different subject areas: eugenics, the insurance industry, the ...