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Autoantibodies
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Pathogenic Advances and Therapeutic Perspectives for Eosinophilic Inflammation
With the recent approval of the first eosinophil-depleting therapeutic agents targeting the IL-5 pathway for treatment of severe eosinophilic asthma, eosinophils and eosinophilic disorders are in the limelight. Indeed, setbacks during clinical development of these compounds have revealed how much remains to be known about eosinophil biology in vivo, and have nurtured profuse research both on basic eosinophil biology and on pathogenic disease mechanisms, in order to better delineate the most meaningful targets for innovative therapeutic strategies. On one hand, variable degrees of eosinophil depletion observed in some compartments during IL-5-targeted treatment indicate that certain eosinophi...
Melanoma Techniques and Protocols
This book is about melanoma—its biology, immunology, and pathology, as well as the initial use of powerful genomic tools to study its fundamental mole- lar and genetic characteristics. The study of cancer will be profoundly impacted by the Human Genome Project. I would like to discuss some of these changes. The first draft of the human genome sequence was announced in June 2000, and we have just scratched the surface of the changes it will engender in medicine. A relevant question is what are the long-term effects of the Human Genome Project for medicine? I would argue that there are three, and each of these three point toward the view that systems biology will dominate biology and medicin...
The Hurdy-Gurdy in Eighteenth-Century France
The hurdy-gurdy, or vielle, has been part of European musical life since the eleventh century. In eighteenth-century France, improvements in its sound and appearance led to its use in chamber ensembles. This new and expanded edition of The Hurdy-Gurdy in Eighteenth-Century France offers the definitive introduction to the classic stringed instrument. Robert A. Green discusses the techniques of playing the hurdy-gurdy and the interpretation of its music, based on existing methods and on his own experience as a performer. The list of extant music includes new pieces discovered within the last decade and provides new historical context for the instrument and its role in eighteenth-century French culture.
