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Parkinsonism of various types has long been a debilitating and cruel affliction for significant numbers of people, and even today the cure remains elusive. The present volume explores the colorful and sometimes alarming history of the attempts to provide at least some relief from the symptoms of this disorder, commencing with interesting reports from ancient India and medieval Europe and continuing until the present time. Especial attention is devoted to L-DOPA therapy, still the leading pharmacological approach to the disorder more than forty years after its first application, and its place in the development of neurochemistry. But the employment of solanaceous plant alkaloid-based therapie...
Progress in Medicinal Chemistry
This book is a sequel to my "Atlas of Topographi sor A.L. Rhoton, Professor K. Sugita and particu larly Professor M.G. Ya{sect}argil (with operation dem cal Anatomy of the Brain and Surrounding Struc tures". Like the first volume it is addressed mainly onstrations in Ziirich), as well as recent descrip to neurosurgeons, neurologists and neuro tions of operations, provided important stimuli. The pathologists. Although the two books deal with dif conversations held with my colleagues were also important for the production of this Atlas. I am par ferent aspects of the subject, that is, the first with anatomical relationships and the present work with ticularly grateful to Dr. J. Gilsbach, Dr. H...
The comparative global history of mental health care in the twentieth century remains relatively uncharted territory. Psychiatric Cultures Compared offers an overview of various national psychiatric cultures, comparing, for example, advances in Dutch psychiatry with developments abroad. Wide-ranging essays cover analyses of the field of psychiatric nursing, the changing use of psychotropic medicine, the emergence of in- and outpatient mental health sectors, the rise of the anti-psychiatry movement, and a critical look at modern day deinstitutionalization.
The growth of neurochemistry, molecular biology, and biochemical genetics has led to a burgeoning of new information relevant to the pathogenesis of brain dysfunction. This explosion of exciting new information is crying out for collation and meaningful synthesis. In its totality, it defies systematic summa tion, and, of course, no one author can cope. Thus invitations for contributions were given to various experts in areas which are under active investigation, of current neurological interest, and pregnant. Although this project is relatively comprehensive, by dint of size, other topics might have been included; the selection was solely my responsibility. I believe systematic summation a v...
"Adapt or perish, now as ever, is Nature's inexorable imperative. " -H. G. Wells, Mind at the End of Its Tether (1946) Doctors are trained to treat people suffering from various diseases. This is the main form of their activity and usually the reason for which they selected medicine as their profession. The notion that they should become managers and engage in activi ties such as programming, calculating cost, assessing cost-benefit ratios, and thinking about pricing in accordance with the social utility of their intervention, is both foreign and abhorrent to them. They are sometimes willing to say how much they need in order to have a well-functioning service: usually they prefer to state w...