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Bioenergetics of the Cell: Quantitative Aspects
This volume continues the discussion of the problems of in vivo and in vitro. The recently solved X-ray structure of the mitochondrial creatine kinase and its molecular biology cellular bioenergetics - the tradition we started in 1994 by publication of the focused issue of Molecular and Cellular are analyzed with respect to its molecular physiology and Biochemistry, volume 133/134 and a book 'Cellular Bio functional coupling to the adenine nucleotide translocase, as energetics: role of coupled creatine kinases' edited by V. Saks well as its participation, together with the adenylate kinase and R. Ventura-Clapier and published by Kluwer Publishers, system, in intracellular energy transfer. Th...
Detection of Mitochondrial Diseases
In October 1995, the 1st Colloquium on Mitochondria and Myopathies in Halle/Saale was organized in Halle/Saale by the editors of this focused issue. The meeting took up what might be called an East German tradition: from 1976 to 1990 Andreas Schmidt organized seven clinically orientated Colloquia on Myology in Jena, and from 1974 to 1990 a series of twelve Colloquia on Mitochondria focused on basic research aspects was arranged by Wolfgang Kunz in Magdeburg. At those meetings, East Germany was a mediator between East European, West European and American scientists. In continuation of this tradition, scientists from more than 17 countries working on mitochondria as neurologists, biochemists, ...
Natural Products Isolation
This new book encompasses, in great detail, the most recent progress made in the isolation and separation of natural products. It covers antibiotics, marine and plant-derived substances, enzyme inhibitors and interferons. The most recent separation methodology is described. Although there is a bias toward antibiotics, it was done because this is still the largest natural products area of research.The fourteen chapters are written by experts in their respective fields. The first two chapters are largely devoted to new methodology applied to purification of a variety of compounds. They include an extensive review and new applications of counter-current chromatography and the newly emerging HPL...
Creatine Kinase
Creatine kinases and arginine kinases are an historical model in enzymology. They belong to the large family of phosphagen kinases which transfer a phosphoryl group from ATP to a nitrogen atom within a guanidinium group to form that was called by the early muscle physiologists a 'phosphagen'. These compounds and the enzymes that catalyse their formation and use are present in cells with important and rapidly fluctuating energy requirements.
Cellular Bioenergetics: Role of Coupled Creatine Kinases
Most of the information on the functional role, structure and molecular biology of creatine kinase is scattered in several hundreds of publications. The editors of this volume invited all authors who are most active at present in experimental research on creatine kinases to summarize their work and make the information easily available to a wider scientific audience, especially to young investigators who are entering this field. Since the functional role of coupled creatine kinases is directly related to the phenomenon of compartmentation and structural organization of metabolic networks, we also invited experts in the related areas to contribute to the volume. Almost all invited authors responded enthusiastically and the results of this collective work are presented here. For biochemists, biophysicists, physiologists, and medical research workers.
Prevention Effectiveness
As public accountability has increased and resources have become scarcer, public health, like clinical medicine, has been forced to re-examine the benefits and costs of its activities. Decision and economic analysis are basic tools in carrying out that mission. These methods have become standard practice in clinical medicine and health services research. This book , now in its second edition, was written in an effort to apply and adapt that experience with public health situations.The book was originally written to introduce Centers for Disease Control and Prevention staff to the concepts of decision and economic analysis, to provide guidance on methods to maximize comparability of studios, ...
Asymmetries In Time
Time is generally thought to be one of the more mysterious ingredients of the universe. In this intriguing book, Paul Horwich makes precise and explicit the interrelationships between time and a large number of philosophically important notions. Ideas of temporal order and priority interact in subtle and convoluted ways with the deepest elements in our network of basic concepts. Confronting this conceptual jigsaw puzzle, Horwich notes that there are glaring differences in how we regard the past and future directions of time. For example, we can influence the future but not the past, and can easily gain knowledge of the past but not of the future. Moreover we see a profusion of decay processe...
Automated Technology for Verification and Analysis
This book constitutes the refereed proceedings of the 18th International Symposium on Automated Technology for Verification and Analysis, ATVA 2020, held in Hanoi, Vietnam, in October 2020. The 27 regular papers presented together with 5 tool papers and 2 invited papers were carefully reviewed and selected from 75 submissions. The symposium is dedicated to promoting research in theoretical and practical aspects of automated analysis, verification and synthesis by providing an international venue for the researchers to present new results. The papers focus on neural networks and machine learning; automata; logics; techniques for verification, analysis and testing; model checking and decision procedures; synthesis; and randomization and probabilistic systems.
