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Our understanding of the universe has been revolutionized by observations of the cosmic microwave background, the large-scale structure of the universe, and distant supernovae. These studies have shown that we are living in a strange universe: 96% of the present day energy density of the universe is dominated by so-called dark matter and dark energy. But we still do not know what dark matter and dark energy actually are. This book presents lectures from the 186th Course in the Enrico Fermi International School of Physics entitled New Horizons for Observational Cosmology, held in Varenna, Italy, in July 2013. Topics covered at this school included: cosmic microwave background anisotropies; ga...
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Rectal cancer is one of the most prevalent cancers world-wide. It is also a paradigm for multimodal management, as the combination of surgery, chemotherapy and radiotherapy is often necessary to achieve the optimal outcome. Recently, international experts met in Heidelberg, Germany to discuss the latest developments in the management of rectal cancer, including the anatomic and pathologic basis, staging tools, surgical concepts including fast-track surgery and laparoscopic resection, functional outcome after surgery and the role of radio- and chemotherapy. This monograph summarizes this meeting and gives an extensive overview of the current concepts in management of rectal cancer.