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Drug Determination in Therapeutic and Forensic Contexts
Acknowledgements. - Valuable support for the Forum came from the Cancer Research Campaign, from Johnson Matthey & Co., and from U. K. pharmaceutical companies - Beechams, Glaxo, ICI and Smith, Kline & French. Moreover, some speakers came without full financial coverage. The choice of presentations was guided by Honorary Advisers including Drs. S.H. Curry (Chairman), J.A.F. de Silva, L.E. Martin, J. Chamberlain and G.G. Skellern. Drs. Jim Leppard and Joan Reid are thanked for Index drafting. As mentioned in the text, some Figs. have already appeared in journals, whose publishers (e.g. Elsevier, Dekker, Preston) are thanked: sources include Journal of Chroma- tography, Journal of Liquid Chroma...
The Age Annual
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Advances in Medicinal Chemistry
Volume 5 of Advances in Medicinal Chemistry contains four intriguing and detailed accounts of the close interface between synthetic chemistry, structure-activity relationships, biochemistry, and pharmacology. In Chapter 1, there is a comprehensive survey of the immunophilin area specifically focussing on neuroregenerative applications in the central nervous system. In Chapter 2, there is an overview of the development of a potent analgesic compound that works via modulation of neuronal nicotinic acetylcholine receptors. In Chapter 3, there is a description of dopamine D-2 autoreceptor partial agonists as potential therapy for the treatment of schizophrenia. In Chapter 4, there is a summary of the successful program in which potent non-peptide inhibitors of HIV protease from the AIDS virus were developed.
