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Understanding Tuberculosis
In 1957, a Streptomyces strain, the ME/83 (S.mediterranei), was isolated in the Lepetit Research Laboratories from a soil sample collected at a pine arboretum near Saint Raphael, France. This drug was the base for the chemotherapy with Streptomicine. The euphoria generated by the success of this regimen lead to the idea that TB eradication would be possible by the year 2000. Thus, any further drug development against TB was stopped. Unfortunately, the lack of an accurate administration of these drugs originated the irruption of the drug resistance in Mycobacterium tuberculosis. Once the global emergency was declared in 1993, seeking out new drugs became urgent. In this book, diverse authors focus on the development and the activity of the new drug families.
Natural Product Chemistry for Drug Discovery
This text provides a comprehensive summary of where natural product chemistry is today in drug discovery. It covers emerging technologies and case studies and is a source of up-to-date information on the topical subject of natural products.
Long-Term Consequences of Adolescent Drug Use: Evidence from Pre-Clinical and Clinical Models
The purpose of this collection is to provide a forum to integrate pre-clinical and clinical investigations regarding the long-term consequences of adolescent exposure to drugs of abuse. Adolescence is characterized by numerous behavioral and biological changes, including substantial neurodevelopment. Behaviorally, adolescents are more likely to engage in risky activities and make impulsive decisions. As such, the majority of substance use begins in adolescence, and an earlier age of onset of use (<15 yr) is strongly associated with the risk for developing a substance use disorder later in life. Furthermore, adolescent drug use may negatively impact ongoing neurological development, which cou...
Stable Isotope Probing and Related Technologies
The ideal starting point for investigating, developing, and implementing stable isotope technologies. • Guides researchers through basic, tested, and proven protocols including DNA, RNA, protein, and phospholipid fatty acid (PLFA) SIP, from concept and history through detailed methodology, troubleshooting, and interpretation to optimal and future uses. • Explores important and emerging applications of SIP in environmental microbiology, ranging from bioremediation and gene mining to carbon tracking and gut microflora function. • Examines explorations of further elegant isotope labeling technologies such as Raman-FISH, NanoSIMS, and isotope arrays. • Serves as a valuable resource for environmental microbiology students and researchers and genomics, biotechnology, and medical microbiology professionals.
Advances in Bioinformatics and Computational Biology
This book constitutes the refereed proceedings of the Brazilian Symposium on Bioinformatics, BSB 2005, held in Sao Leopoldo, Brazil in July 2005. The 15 revised full papers and 10 revised extended abstracts presented together with 3 invited papers were carefully reviewed and selected from 55 submissions. The papers address a broad range of current topics in computational biology and bioinformatics.
Substance Use Disorders
Written by experienced clinicians and researchers, this book provides a comprehensive overview of substance use disorders. It integrates evidenced-based practices with clinical wisdom of practitioners from several disciplines. Most importantly, this book provides practical strategies to help patients with substance use disorders in a range of treatment settings.
Additive Manufacturing in Pharmaceuticals
This book presents the different 3D/4D printing technological applications of Additive Manufacturing (AM) in Pharmaceutical Sciences. The initial chapter provides the historical perspective and current scenario of AM in pharmaceuticals. The book further discusses about different 3D printing platform technologies such as FDM, SLA, SLS, SSE, Ink-jet & binder jet principles & applications in developing advanced drug delivery systems. It also covers the methodology, materials for AM and important parameters associated with these platform technologies. The book highlights the progress and practical applications of 4D-printing technology in healthcare & pharmaceuticals fraternity as well including the essence of bioprinting in pharmaceuticals. Finally, the book reviews the regulatory guidelines, perspectives, and integration of Artificial Intelligence (AI)/Machine learning (ML) in pharmaceutical AM. This book is indeed a valuable resource for students, researchers/scholars, young start-ups/entrepreneurs, and pharmaceutical professionals by providing thorough detailing about AM in Pharmaceuticals.
The Unfinished Game
Before the mid-seventeenth century, scholars generally agreed that it was impossible to predict something by calculating mathematical outcomes. One simply could not put a numerical value on the likelihood that a particular event would occur. Even the outcome of something as simple as a dice roll or the likelihood of showers instead of sunshine was thought to lie in the realm of pure, unknowable chance. The issue remained intractable until Blaise Pascal wrote to Pierre de Fermat in 1654, outlining a solution to the "unfinished game" problem: how do you divide the pot when players are forced to.
