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The Quinolones
Quinolones constitute a large class of synthetic antimicrobial agents that are highly effective in the treatment of many types of infectious diseases, particularly those caused by bacteria. New quinolones are continually being developed as bacterial species develop resistance to existing quinolones. This book presents the most current information available in our continual struggle to conquer disease. Over time, bacteria become resistant to medicines that are used to combat them. Because of this, the medical world is always in search of new and improved ways to battle these disease-causing bacteria. Quinolones are at the forefront of this research. Edited by one of the world's foremost autho...
Drug Toxicity in Embryonic Development II
Having received the invitation from Springer-Verlag to produce a volume on drug-induced birth defects for the Handbook of Experimental Pharmacology, we asked ourselves what new approach could we offer that would capture the state of the science and bring a new synthesis of the information on this topic to the world's literature. We chose a three-pronged approach, centered around those particular drugs for which we have a relatively well established basis for understanding how they exert their unwanted effects on the human embryo. We then supplemented this information with a series of reviews of critical biological processes involved in the established normal developmental patterns, with emph...
The Antimicrobial Drugs
For this updated edition, the treatment of the mechanisms of action, pharmacology and adverse effects of the drugs used to treat bacterial, fungal, parasitic and viral infections has been expanded. This edition also includes new chapters on the fluoroquinolones and drugs used to treat AIDS.
PCBs
Though polychlorinated biphenyls (PCBs) have been banned in the United States for more than thirty years, the toxic effects of their presence in local environments continue to be a significant public health concern. PCBs: Human and Environmental Disposition and Toxicology brings together more than fifty established specialists on PCB toxicity to discuss recent trends and specialized investigations of PCB influences on the environment and on humans. Renowned scientists including Paul S. Cooke, Takeshi Nakano, Tomas Trnovec, Deborah C. Rice, Linda S. Birnbaum, and Charles S. Wong present cutting-edge research on Hudson River PCBs, human contamination, homologue profiles, high PCB exposure in Slovakia, and PCB effects on the thyroid hormone, nutrition, and estrogen levels in humans and animals. Focusing on the detection, movement, metabolism, toxicity, remediation, and risk assessment of PCB contamination, this multi-disciplinary study is a valuable resource for regulatory agencies and scientists working with PCBs.
Risk Assessment of Prenatally-Induced Adverse Health Effects
Since the thalidomide (Contergan) tragedy about 30 years ago the induction of prenatally-induced morphological or functional defects has been an area of extensive research. Risk assessment of prenatally-induced adverse health effects is still a difficult task from both experimental data as well asfrom observations in humans. In the contributions to this book three major aspects are dealt with: - Quantitative extrapolations of experimental data to the situation possibly relevant for man. - The significance for a risk assessment with respect to man of minor or rare structural abnormalities observed in experimental studies - The future need to assess congenital dysfunctions (e.g. of the hormone or the immune system) beside the present evaulation of structural defects. Limitations as well as gaps of the present knowledge in this area of basic and applied research are pointed out. Since the results of prenatally-induced lesions may manifest themselves not only pre- but often not before late postnatally, numerous aspects of structural and functional abnormaldevelopment must be studied in experimental and clinical investigations.
The Thymus in Immunotoxicology
"Thymus Update 4" details the sensitivity of the thymus to xenobiotics and their effects on thymocyte development and maturation. It highlights the importance of immunological testing of all envoronmental toxins, such as dioxin, tin compounds and caramel additives, and drugs, such as immunosuppressives, antiviral agents and antihypertensive agents. The effects of trauma are also considered. Part two covers a subject of topical importance: an update on procedures for vascular transplantation of the thymus.
