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Principles of Free-Electron Lasers
At the time that we decided to begin work on this book, several other volumes on the free-electron laser had either been published or were in press. The earliest work of which we were aware was published in 1985 by Dr T. C. Marshall of Columbia University [1]. This book dealt with the full range of research on free-electron lasers, including an overview of the extant experiments. However, the field has matured a great deal since that time and, in our judgement, the time was ripe for a more extensive work which includes the most recent advances in the field. The fundamental work in this field has largely been approached from two distinct and, unfortunately, separate viewpoints. On the one han...
Developments in T Cell Based Cancer Immunotherapies
This volume illustrates the salient aspects of cancer biology relevant to the successful implementation of immunotherapy. Topics include enhancement of antigen-specific immune responses by anti-cancer vaccines, modulation of the function of T cells within the tumor microenvironment, and the effects of genetic, epigenetic, developmental, and environmental determinants on T cell function. Other topics covered include the ex vivo expansion of T or other immune cells and their genetic modification or reprogramming to increase their ability to survive and expand when adoptively transferred back to the patients. Specific attention is devoted to the genetic manipulation of T cells through the introduction of re-directed T cell receptors, chimeric antibody receptors, and other genetic manipulation aimed at improving their effectiveness as anti-cancer agents. Furthermore, the revolutionary role of checkpoint inhibitors and their potential in combination with other immunotherapeutic approaches or with standard chemo and radiation therapy are extensively discussed.
Immunotherapy in Translational Cancer Research
A guide to state-of-the-art cancer immunotherapy in translational cancer research A volume in the Translational Oncology series, Immunotherapy in Translational Cancer Research explores the recent developments in the role that immunotherapy plays in the treatment of a wide range of cancers. The editors present key concepts, illustrative examples, and suggest alternative strategies in order to achieve individualized targeted therapy. Comprehensive in scope, Immunotherapy in Translational Cancer Research reviews the relevant history, current state, and the future of burgeoning cancer-fighting therapies. The book also includes critical information on drug development, clinical trials, and govern...
Evidence-Based Practice Manual
The Evidence-Based Practice Manual was developed as an all-inclusive and comprehensive practical desktop resource. It includes 104 original chapters, each specially written by the most prominent and experienced medical, public health, psychology, social work, criminal justice, and public policy practitioners, researchers, and professors in the United States and Canada. This book is specifically designed with practitioners in mind, providing at-a-glance overviews and direct application chapters. This is the only interdisciplinary volume available for locating and applying evidence-based assessment measures, treatment plans, and interventions. Particular attention has been given to providing p...
Engineering in Translational Medicine
This book covers a broad area of engineering research in translational medicine. Leaders in academic institutions around the world contributed focused chapters on a broad array of topics such as: cell and tissue engineering (6 chapters), genetic and protein engineering (10 chapters), nanoengineering (10 chapters), biomedical instrumentation (4 chapters), and theranostics and other novel approaches (4 chapters). Each chapter is a stand-alone review that summarizes the state-of-the-art of the specific research area. Engineering in Translational Medicine gives readers a comprehensive and in-depth overview of a broad array of related research areas, making this an excellent reference book for sc...
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Digestive Diseases in the United States
This is a compendium of descriptive statistics on digestive diseases in the United States. Each chapter provides analyses of primary data from recent, large U.S. surveys as well as an interpretative review of the known epidemiology of each disease or condition. These statistics cover both specific diseases as well as conditions or syndromes, specific digestive symptoms, and gastrointestinal procedures. Topics covered include cost of digestive diseases in the United States; infectious diarrheas; viral hepatitis; esophageal cancer; gastric cancer; colorectal cancer; liver cancer; pancreatic cancer; hemorrhoids; esophageal diseases; peptic ulcer; gastritis/nonulcer dyspepsia; acute appendicitis; abdominal wall hernia; inflammatory bowel diseases; diverticular disease of the colon; constipation; irritable bowel syndrome; chronic liver disease and cirrhosis; gallstones; pancreatitis; etc.
Bone-Metabolic Functions and Modulators
Recent research, which Bone- Metabolic Function and Modulators expands on, has added new support to the idea that bone not only serves as a support system, but also functions as an integrating organ, with a significant regulatory role for lipid and energy metabolism. Links between physical activity and the skeleton are also becoming increasingly clear. This fully illustrated volume contains up-to-date information on the metabolic role of the skeleton and what this can mean for the treatment of metabolic as well as skeletal and auditory diseases. Bone- Metabolic Function and Modulators is of particular interest to clinician scientists, clinical and basic bone researchers, orthopedists, endocr...
