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The transmission route used by many bacterial pathogens of clinical importance includes a step outside the host; thereafter refer to as the non-clinical environment (NCE). Obvious examples include foodborne and waterborne pathogens and also pathogens that are transmitted by hands or aerosols. In the NCE, pathogens have to cope with the presence of toxic compounds, sub-optimal temperature, starvation, presence of competitors and predators. Adaptation of bacterial pathogens to such stresses affects their interaction with the host. This Research Topic presents important concept to understand the life of bacterial pathogens in the NCE and provides the reader with an overview of the strategies used by bacterial pathogens to survive and replicate outside the host.
The volume brings together all of the latest research on this pathogen, the interest in which is rapidly growing. Legionella pneumophila is an emerging human pathogen that resides in natural environments as a parasite of freshwater. There have been major new developments in this field, including the publication of three whole genome sequences and the discovery of a developmental cycle and novel cyst-like highly infectious form.
Preventing Legionellosis covers the biology of Legionella and presents a comprehensive review of best practices for legionellosis prevention from around the world. Recent outbreaks, climbing incidence rates and pending lawsuits have raised public awareness about legionellosis, a serious, preventable form of pneumonia that can be contracted from water systems in buildings. Legionellosis has harmed millions of people worldwide and causes annual monetary losses in the billions. However, to really understand the effects of the disease, one must listen carefully as the victims, or their survivors, describe the suffering they have endured. Preventing Legionellosis provides concise detail for: Improving awareness and education Implementing water management plans Mitigating against commercial conflict of interest The book will give the scientific basis for the worldwide technical consensus on the prevention of legionellosis. It will be an invaluable source of information for public health administrators, epidemiologists, infection control professionals, facility safety managers, industrial hygienists, and academic engineers and scientists.
This book, Mechanisms in the Pathogenesis of Enteric Diseases, is the outcome of the First International Rushmore Conference on Mechanisms in the Pathogenesis of En teric Diseases, held in September 1995 at Rapid City, South Dakota. The meeting was or ganized by members of the North-Central Regional Research Committee "NC-62," a United States Department of Agriculture-sponsored consortium of swine enteric disease researchers from land-grant institutions. This conference was conceived as a forum for an interdisciplinary discussion of mechanisms of infectious diseases. It was intended that such a discussion would stimulate cross-fostering of ideas and nurture synergistic collabo rations among ...
Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections is a complete examination of the ways in which proteins with more than one unique biological action are able to serve as virulence factors in different bacteria. The book explores the pathogenicity of bacterial moonlighting proteins, demonstrating the plasticity of protein evolution as it relates to protein function and to bacterial communication. Highlighting the latest discoveries in the field, it details the approximately 70 known bacterial proteins with a moonlighting function related to a virulence phenomenon. Chapters describe the ways in which each moonlighting protein can function as such for a variety of bacteria...
Microbial infection is increasingly seen as a problem as we begin to run out of antibiotics. Understanding how microbes cause disease is essential. In recent years it has begun to emerge that bacteria, fungi, protozoa and viruses can use their cell stress proteins to cause infection. This volume brings together the world's leading experts in the study of the microbial and human cell stress proteins that are involved in enabling microorganisms to infect humans and cause serious disease.
Opportunistic, intracellular bacterial infections are at the forefront of research because of the challenges they present to immunocompromised patients. In this volume, the pathogenesis and immune reaction of these intracellular infections is featured, as are the most typical problems related to antimicrobial chemotherapy, and current approaches to their solution. Individual chapters set the pace for research on pathogenic and immune reactions to such infections as, mycobacterium tuberculosis, legionella pneumophila, chlamydia trachomatis and brucella.
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