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Managing Inflammatory Arthritis
We think that inflammatory arthritis is sometimes caused by immune responses to food proteins and encourage everyone with arthritis to give diet revision a try. Several diet revision studies have shown benefit for patients with rheumatoid arthritis. These studies support the more common and persistent claims in the community that diet revision has benefits. Carinini and Brostoff reviewed the concepts of and evidence for food-induced arthritis. They stated: "Despite an increasing interest in food allergy and the conviction of innumerable patients with joint disease that certain foods exacerbate their symptoms, relatively little scientific attention has been paid to this relationship. Abnormal...
Challenges Associated with Identifying Preclinical Animal Models for the Development of Immune-based Therapies
There hasn’t been a better time to be a drug developer for immune-based therapies than the past couple of decades. We have seen an explosion in immune-based therapies for cancer, autoimmune and infectious diseases, metabolic diseases and diseases and disorders of the nervous system. The modalities of these immune-based therapies span small molecules, biologics, and gene and cell therapeutic approaches. Significant advances have been made in optimizing drug design for its specificity for the target, characterizing the mode of action in in vitro assays, and ensuring safety and manufacturability. However, an area of challenge that remains is identifying animal models for evaluating efficacy and pharmacokinetics/pharmacodynamics relationship that are predictive of drug effects in humans. Discussion on this topic is warranted as examples of failures of translation from animal models to humans provide us an opportunity to learn more about human biology.
Fluorescent Methods to Study Biological Membranes
Biological membranes play a central role in cell structure, shape and functions. However, investigating the membrane bilayer has proved to be difficult due to its highly dynamic and anisotropic structure, which generates steep gradients at the nanometer scale. Due to the decisive impact of recently developed fluorescence-based techniques, tremendous advances have been made in the last few years in our understanding of membrane characteristics and functions. In this context, the present book illustrates some of these major advances by collecting review articles written by highly respected experts. The book is organized in three parts, the first of which deals with membrane probes and model me...
Lipid Rafts and Caveolae
This keenly awaited first overview of the field represents a complete guide to the structure and function of the most important mammalian cell membrane organelles. Filling a huge gap in the primary literature, this book is the first to cover the subject in detail. Following an introduction by Kai Simons, the discoverer of lipid rafts and the most prominent scientist in the field, chapters include: Historical background Distinct structures and functions Structural basis Signaling Viral entry and virion budding Cholesterol transport Caveolins Lipid shells Cell polarity and intracellular trafficking Cancer cells Of prime importance to molecular and cell biologists, biochemists, membrane scientists, cancer researchers, and virologists.
Artificial Immune Systems
This book constitutes the refereed proceedings of the 11th International Conference on Artificial Immune Systems, ICARIS 2012, held in Taormia, Italy, in August 2012. The 19 revised selected papers presented were carefully reviewed and selected for inclusion in this book. In addition 4 papers of the workshop on bio and immune inspired algorithms and models for multi-level complex systems are included in this volume. Artificial immune systems (AIS) is a diverse and maturing area of research that bridges the disciplines of immunology, biology, medical science, computer science, physics, mathematics and engineering. The scope of AIS ranges from modelling and simulation of the immune system through to immune-inspired algorithms and in silico, in vitro and in vivo solutions.
AACR 2017 Proceedings: Abstracts 1-3062
The AACR Annual Meeting highlights the best cancer science and medicine from institutions all over the world. Attendees are invited to stretch their boundaries, form collaborations, attend sessions outside their own areas of expertise, and learn how to apply exciting new concepts, tools, and techniques to their own research. Part A contains abstracts 1-3062 accepted for the 2017 meeting.
Artificial Immune Systems
This book constitutes the refereed proceedings of the 10th International Conference on Artificial Immune Systems, ICARIS 2011, held in Cambridge, UK, in July 2011. The 37 revised full papers were carefully reviewed and selected from numerous submissions. The papers are organized in topical sections on immunoinformatics and computational immunology; theory of immunological computation; and applied immunological computation.
Imaging and Spectroscopic Analysis of Living Cells
This volume of Methods in Enzymology is the second of three parts looking at current methodology for the imaging and spectroscopic analysis of live cells. The chapters provide hints and tricks not available in primary research publications. It is an invaluable resource for academics, researchers and students alike. Expert authors who are leaders in the field Extensively referenced and useful figures and tables Provides hints and tricks to facilitate reproduction of methods
Artificial Immune Systems
This book constitutes the refereed proceedings of the 10th International Conference on Artificial Immune Systems, ICARIS 2011, held in Cambridge, UK, in July 2011. The 37 revised full papers were carefully reviewed and selected from numerous submissions. The papers are organized in topical sections on immunoinformatics and computational immunology; theory of immunological computation; and applied immunological computation.
