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Translational Informatics
The book provides readers the informatics and data-driven models for the discovery of personalized excise prescriptions applied to different cases. Overdiagnosis or over-treatment often happened since the complex interaction among the lifestyle, genetic, and environmental factors. Sports and exercise are reported efficient to prevent or reduce the risk of diseases, but the interactions between sports/exercise and disease are personalized and complex. Translational informatics is a powerful paradigm and it promotes the transfer of big data, knowledge and models to the precision application of sports to prevent diseases. Sports and exercise may have different effects on diverse diseases includ...
Specialized Metabolites from Medicinal Plants: the Structural Identification, Biological Activity and Biosynthesis Pathways
Morphine, extracted/isolated from the opium poppy, was the first plant-derived natural product, which was first reported in 1806 and marked as the beginning of plant metabolites research. In the following 200 years, many specific metabolites with significant bio-activity, such as quinine, artemisinin, and paclitaxel, were discovered in plant-derived medicines and have been used for treating human diseases. The extracts of plants or their metabolites have contributed significantly to human health, particularly in the treatment of chronic diseases such as diabetes, hypertension, and obesity. Nowadays, medicinal plants and their metabolites are increasingly favored by researchers and pharmaceutical companies to be developed as new dietary supplements and pharmaceuticals. Therefore, screening and identification of novel active metabolites or lead compounds from plant-derived medicines for human disease treatment have become a popular research area.
Artificial Intelligence in Medical Virology
This book comprehensively reviews the potential of Artificial Intelligence (AI) in biomedical research and healthcare, with a major emphasis on virology. The initial chapter presents the applications of machine learning methods for structured data, such as the classical support vector machine and neural network, modern deep learning, and natural language processing for unstructured data in biomedical research and healthcare. The subsequent chapters explore the applications of AI in tackling COVID-19, analysis of the pandemic, viral infection, disease spread, and control. The book further identifies the potential applications of machine learning in the field of virology with a focus on the ke...
Indian Herbal Medicines
This book discusses the scope and limitations of the antimicrobial and antioxidant properties of foods as medicines or medicinal coadjuvants in traditional Indian herbal therapies. The first chapter introduces readers to the relevance of the Ayurveda system, its holistic classification approach, applications of selected herbs and the demonstrable efficacy of herbal extracts in terms of antimicrobial susceptibility. In turn, the second chapter discusses the antimicrobial properties and kinetic mechanisms of inhibition ascribed to selected vegetable extracts. The third chapter addresses the antioxidant power of phenolic compounds from vegetable products and herbal extracts. The book closes with a review of natural antioxidant agents’ role in the treatment of metabolic disorders. Written from an Indian perspective, this book unravels the chemistry of the traditional Indian diet and its impact on health. Further, it can serve as a reference for other traditional products with similar health claims.
Nanoarchitectonics for Brain Drug Delivery
This book discusses basics of brain diseases and the role of nanobiotechnology in existing treatment options for neurodegenerative disorders. It begins with an overview of brain diseases and the need for novel drug-delivery approaches. It highlights the current route for the intranasal advanced drug-delivery systems for brain diseases. It also discusses innovative categories of drug-delivery systems, including mesoporous silica nanoparticles, polymeric nanocarriers, and lipid-based nanocarriers through multi-responsive DDSs and their implications in brain disorders. Features: Includes an overview of brain diseases and highlights the need for novel drug-delivery approaches Focuses on theoreti...
Computational Approaches in Drug Discovery, Development and Systems Pharmacology
Computational Approaches in Drug Discovery, Development and Systems Pharmacology provides detailed information on the use of computers in advancing pharmacology. Drug discovery and development is an expensive and time-consuming practice, and computer-assisted drug design (CADD) approaches are increasing in popularity in the pharmaceutical industry to accelerate the process. With the help of CADD, scientists can focus on the most capable compounds so that they can minimize the synthetic and biological testing pains. This book examines success stories of CADD in drug discovery, drug development and role of CADD in system pharmacology, additionally including a focus on the role of artificial in...
CRISPR-Cas System in Translational Biotechnology
CRISPR-Cas System in Translational Biotechnology discusses applied and translational aspects of the CRISPR-Cas technology. The book bridges the gap between theoretical knowledge and practical solutions surrounding this emerging and impactful technology in several academic and industrial fields. It is split in five sections: CRISP-Cas fundamentals and advancements; CRISP-Cas in medical biotechnology; CRISP-Cas in environmental biotechnology; CRISP-Cas in food biotechnology; and biosafety, patents and commercialization of CRISP-Cas technology. Written by experts from diverse backgrounds, the content covers the subject and its impact in multiple fields. It is a valuable resource for graduate st...
The Chemistry of Biofilms and Their Inhibitors
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
