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Autoimmune Blistering Diseases
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Blistering Diseases
This book is a comprehensive compendium of current knowledge on inherited and autoimmune blistering diseases that relates advances in our understanding of the pathogenetic mechanisms to management of the individual diseases. The aim is to provide a detailed reference for dermatologists who care for patients with these conditions and a useful “one-stop information shop” for specialists outside of dermatology. The book opens by describing the structure and biology of the epidermis and basement membrane zone and discussing the genes and proteins that are targets for mutations and autoantibodies. The role of the various diagnostic tests is explained, and clinical manifestations of the specific diseases are presented with the aid of many high-quality illustrations. The forms of treatment appropriate in specific conditions are then described in depth, with coverage of dressings, drugs, surgical procedures, gene therapy, and other novel approaches. Helpful algorithms are included both for testing and monitoring and for treatment.
AutoImmune Blistering Disease Part I, An Issue of Dermatologic Clinics
In the first volume of this two part issue devoted to Autoimmune Blistering Diseases (AIBD), diagnosis and clinical features of these diseases are covered by an internationally recognized group of authors. Topics include Pemphigus Vulgaris, Pemphigus Foliaceus, Linear IgA Bullous Disease, and Hair and Nail Loss in AIBD.
Clinical Immunology E-Book
Offering unique, comprehensive coverage of both basic science and clinical scenarios, Clinical Immunology: Principles and Practice, 6th Edition, brings you up to date with every aspect of this fast-changing field. It examines the molecular, cellular, and immunologic bases of immunologic diseases and their broader systemic implications; it also includes complete coverage of common and uncommon immunologic disorders. Updated with all the latest immunologic research and clinical implications, including breakthrough immunotherapies and molecular-based treatment protocols, this fully revised edition provides authoritative guidance from some of the most respected global leaders in immunology in on...
Single-cell analysis on the pathophysiology of autoimmune diseases
Despite increasing research to facilitate the understanding of the pathophysiology of autoimmune disorders, the exact cause of the incident of autoimmunity is unknown. Current concepts on the occurrence of autoimmune diseases are thought to involve autoantigens, genetic predisposition, disease triggers, and the breakdown of immune tolerance. In addition to the breakdown of immunological tolerance, one key characteristic of autoimmune disease is that within a single disease there is considerable variability in the clinical manifestation and severity in patients. Single-cell omics have emerged as an effective means of unraveling the complexity and heterogeneity of chronic disease development and therapeutic responses. Recently, advances in cutting-edge spatial profiling of diverse cell types have increased our understanding of how distinct cells interact and orchestrate at specific locations across a tissue landscape in both physiological and pathological contexts at the single-cell level.
Lymphocyte Homing to the Skin
Over the last decade, enormous progress in the understanding of T-cell homing has made it possible to identify the multitude of molecules involved, such as cytokines, chemokines, and adhesion molecules, and to unravel their complex interactions resulting in controlled, non-random T-cell recirculation. These insights are now being explored therapeut
Macrophages in inflammation and its resolution
Macrophages were initially identified as a key element in the innate host response to infection and injury due to their phagocytic clearance and elimination of pathogenic and non-pathogenic entities. However, as macrophage research advanced it became clear that not only are these cells amenable to the acquisition of multiple plastic phenotypes during inflammatory responses to different pathogens, they also play a paramount role in the termination of inflammation and acquired immune responses. In addition, macrophages profoundly affect host physiology when they migrate to distant sites and differentiate to specialized cells, like foam cells, osteoclasts, adipose tissue- and tumor -associated ...
