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Dhat Syndrome
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Non-biomedical Perspectives on Pain and its Prevention and Management
Overreliance on the biomedical paradigm has contributed, in part, to illogical use of surgery and long-term opioid medication with harmful physical, psychological, social, and economic consequences. Pain literature is dominated by biomedical research at the expense of a holistic understanding of the lived experience of pain. Pain practice seems overly consumed with the burden of pain at an individual level (patient-centred pain management) and has neglected exploration of societal level (community-centred) or environmental level (ecologically-centred) solutions.
The Pharmacotherapy of Depression - Searching for New Mechanisms and Drug Interactions. Basic and Clinical Research, Volume II
Depression is a common mental disorder and one of the leading causes of hospitalization. Simultaneously this disorder is the most notorious vulnerability factor to suicide attempts among men and women. The COVID-19 pandemic (COVID-19-related stressors) resulted in a statistically significant increase in depression incidences. Pharmacological treatment in the clinic is primarily based on substances synthesized in the 1960s and 1970s. High hopes were associated with compounds increasing the level of catecholamines in the brain and reducing excitotoxic levels of glutamate (Glu). However, side effects associated with cognition and psychosis are common. Therefore, it is crucial to synthesize new pharmacologically active substances or combine those used in clinical practice to define further directions in the development of novel more effective therapeutics for depression.
