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Language Lateralization and Psychosis
Illustrates important fundamental aspects of cerebral lateralization, explaining how decreased language lateralization can facilitate psychotic symptoms in the human brain.
Far from the Tree
* * * * * * * BBC Radio 4 Book of the Week * * * * * * * âe~Andrew Solomonâe(tm)s investigation of many of the most intense challenges that parenthood can bring compels us all to re-examine how we understand human difference. Perhaps the greatest gift of this monumental book, full of facts and full of feelings, is that it constantly makes one think, and think again.âe(tm) Philip Gourevitch In this seminal new study of family, Andrew Solomon tells the stories of parents who learn to deal with their exceptional children and find profound meaning in doing so. He introduces us to families coping with deafness, dwarfism, Down syndrome, autism, schizophrenia, disability, with children who are p...
Third-Generation Neuroimaging: Translating Research into Clinical Utility
Psychiatric imaging needs to move away from simple investigations of the neurobiology underling the early phases of psychiatric diseases to translate imaging findings in the clinical field targeting clinical outcomes including transition, remission and response to preventative interventions. This research topic aims to bring psychiatric neuroimaging studies towards translational impacts in clinical practice, suggesting that brain abnormalities may be of potential use for detecting clinical outcomes as treatment response. First-generation psychiatric neuroimaging focused on simple structural brain alterations associated with the neurobiology of the illness. These early studies adopted imaging...
Preventing Suicide in Patients with Mental Disorders
Suicide is a complex phenomenon that is now considered understood as a neurodevelopmental condition encompassing childhood experiences as well as proximal conditions such as mental disorders and adverse life events. Individuals in crisis may face overwhelming psychological pain, which in some cases may overcome the threshold of each unique individual for whom suicide is considered the best option to deal with such pain. However, many socio-demographic, personal, or temperamental variables have been investigated for their causal association with suicide risk, but to date no single factor has clearly demonstrated an association with suicide. The mental disorders most frequently associated with suicide risk include bipolar disorders and major unipolar depression, substance use disorders and schizophrenia. However, anxiety, personality, eating, and trauma-related disorders, as well as organic mental disorders, also contribute to suicidal risk. Moreover, in modern society, the presence of social uncertainty, the changes in family models, the development of social media, and the loss of face-to-face interaction can have an impact on suicide risk, particularly in the younger generation.
Schizophrenia
Leading researchers address conceptual and technical issues in schizophrenia and suggest novel strategies for advancing research and treatment. Despite major advances in methodology and thousands of published studies every year, treatment outcomes in schizophrenia have not improved over the last fifty years. Moreover, we still lack strategies for prevention and we do not yet understand how the interaction of genetic, developmental, and environmental factors contribute to the disorder. In this book, leading researchers consider conceptual and technical obstacles to progress in understanding schizophrenia and suggest novel strategies for advancing research and treatment. The contributors addre...
Neuroimaging in Schizophrenia
This comprehensive book explains the importance of imaging techniques in exploring and understanding the role of brain abnormalities in schizophrenia. The findings obtained using individual imaging modalities and their biological interpretation are reviewed in detail, and updates are provided on methodology, testable hypotheses, limitations, and new directions for research. The coverage also includes important recent applications of neuroimaging to schizophrenia, for example in relation to non-pharmacological interventions, brain development, genetics, and prediction of treatment response and outcome. Written by world renowned experts in the field, the book will be invaluable to all who wish to learn about the newest and most important developments in neuroimaging research in schizophrenia, how these developments relate to the last 30 years of research, and how they can be leveraged to bring us closer to a cure for this devastating disorder. Neuroimaging in Schizophrenia will assist clinicians in navigating what is an extremely complex field and will be a source of insight and stimulation for researchers.
Neural Signal Estimation in the Human Brain
The ultimate goal of functional brain imaging is to provide optimal estimates of the neural signals flowing through the long-range and local pathways mediating all behavioral performance and conscious experience. In functional MRI (Magnetic Resonance Imaging), despite its impressive spatial resolution, this goal has been somewhat undermined by the fact that the fMRI response is essentially a blood-oxygenation level dependent (BOLD) signal that only indirectly reflects the nearby neural activity. The vast majority of fMRI studies restrict themselves to describing the details of these BOLD signals and deriving non-quantitative inferences about their implications for the underlying neural activ...
