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Amyotrophic lateral sclerosis (ALS), which was described since 1869 by Jean Martin Charcot, is a devastating neurodegenerative disease characterized by the selective and progressive loss of upper and lower motor neurons of the cerebral cortex, brainstem and the spinal cord. The cognitive process is not affected and is not merely the result of aging because may occur at young ages. The only known cause of the disease is associated with genetic mutations, mainly in the gene encoding superoxide dismutase 1 (familial ALS), whereas there is no known cause of the sporadic form of ALS (SALS), which comprises >90% of cases. Both ALS types develop similar histopathological and clinical characteristic...
An explosion of little architectural magazines in the 1960s and 1970s instigated a radical transformation in architectural culture, as the magazines acted as a site of innovation and debate. Clip/Stamp/Fold takes stock of seventy little magazines from this period. The book brings together a remarkable range of documents and original research which the project has produced during its continuous travels over the last four years starting with the exhibition at the Storefront in November 2006. The book features transcripts from the “Small Talks” events in which editors and designers were invited to discuss their magazines; a stocktaking of over 100 significant issues that tracks the changing density and progression of the little magazine phenomenon; transcripts of more than forty interviews with magazine editors and designers from all over the world; a selection of magazine facsimiles; and a fold out poster that offers a mosaic image of more than 1,200 covers examined during the research.
Though considerable amount of research, both pre-clinical and clinical, has been conducted during recent years, Amyotrophic Lateral Sclerosis (ALS) remains one of the mysterious diseases of the 21st century. Great efforts have been made to develop pathophysiological models and to clarify the underlying pathology, and with novel instruments in genetics and transgenic techniques, the aim for finding a durable cure comes into scope. On the other hand, most pharmacological trials failed to show a benefit for ALS patients. In this book, the reader will find a compilation of state-of-the-art reviews about the etiology, epidemiology, and pathophysiology of ALS, the molecular basis of disease progression and clinical manifestations, the genetics familial ALS, as well as novel diagnostic criteria in the field of electrophysiology. An overview over all relevant pharmacological trials in ALS patients is also included, while the book concludes with a discussion on current advances and future trends in ALS research.
“The Earth says, God has placed me here. The Earth says that God tells me to take care of the Indians on this earth; the Earth says to the Indians that stop on the Earth, feed them right. . . . God says feed the Indians upon the earth.” —Cayuse Chief Young Chief, Walla Walla Council of 1855 America has always been Indian land. Historically and culturally, Native Americans have had a strong appreciation for the land and what it offers. After continually struggling to hold on to their land and losing millions of acres, Native Americans still have a strong and ongoing relationship to their homelands. The land holds spiritual value and offers a way of life through fishing, farming, and hun...
This book gathers the latest advances, innovations, and applications in the field of multibody and mechatronic systems. Topics addressed include the analysis and synthesis of mechanisms; modelling and simulation of multibody systems; railway and vehicle dynamics; mechatronic systems for energy harvesting; robot design and optimization; and mechatronic design. It gathers the second volume of the proceedings of the 7th International Symposium on Multibody Systems and Mechatronics (MuSMe), virtually held in Cordoba, Argentina, on October 12-15, 2021, within the framework of the FEIbIM Commission for Robotics and Mechanisms and IFToMM Technical Committees for Multibody Dynamics and for Robotics and Mechatronics.
This volume is concerned with metabolic reactions occurring in the nervous system. Some time ago, it was thought that since most of the intermediary metabolism that can be observed in the brain is not specific to this organ, there is little justification in studying neural metabolism as such. Later it was realized that for an understanding of neural functions, the understanding of metabolism in the brain and its alterations is essential. All aspects of the metabolism of a substrate in brain, or all metabolic reactions of the nervous system, could not be included in this volume; some will be dealt with in other volumes (such as the ones covering metabolic turn over, alterations of metabolism,...
This volume is an up-to-date treatise of chemosensory vertebrate research performed by over 200 scientists from 22 countries. Importantly, data from over 25 taxa of vertebrates are presented, including those from human beings. Unlike other volumes on this topic, a significant nurober of the contributions come from leading workers in the former Soviet Union and reflect studies within a wide variety of disciplines, including behavior, biochemistry, ecology, endocrinology, genetics, psychophysics, and morphol ogy. Most of the studies described in this volume were presented at the Chemical Signals in Vertbrates VI (CSV VI) symposium held at the University of Pennsylvania in the summer of 1991. This international symposium was the largest and the most recent of a series of six such symposia, the first of which was held in Saratoga Springe, New York (June 6-9, 1976) and the last in Oxford, England (August 8-10, 1988). Unlike the previous symposia, Chemical Signals in Vertabrates VI lasted a full week, reflecting the increased number of participants and the desire of many to present their research findings orally to the group as a whole.
It is indeed a pleasure to welcome all of you to this Inter national Symposium on the Neurohumoral coding of Brain Function. Many of you have undertaken a very long trip in order to cross swords with some of the most fascinating issues in all of the neurosciences. Of particular satisfaction in this instance is the geographical representation of the sciences with individuals here from Europe and the Americas - South, Central and North. As we do battle, so to speak, with each of the questions raised during the next several days, we should remember that the problems faced by each of our fields are exceptionally difficult. In a way, this difficulty stems from two related facts: (1) we are trying...
This book offers a timely and comprehensive snapshot of research and developments in the fields of dynamic systems and control engineering. Covering a wide range of theoretical and practical issues, the contributions describes a number of different control approaches, such as PID control, adaptive control, nonlinear systems and control, intelligent monitoring and control based on fuzzy and neural systems, robust control systems, and real time control, among others. Sensors and actuators, measurement systems, renewable energy systems, aeronautic and aerospace systems as well as industrial control and automation, are also comprehensively covered. Based on the proceedings of the 15th APCA International Conference on Automatic Control and Soft Computing, held on July 6-8, 2022, in Caparica, Portugal, the book offers a timely and thoroughly survey of the latest research in the fields of dynamic systems and automatic control engineering, and a source of inspiration for researchers and professionals worldwide.