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Drug Delivery to the Brain
The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood –brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper...
Doctor Thorne
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Gravitation
Spacetime physics -- Physics in flat spacetime -- The mathematics of curved spacetime -- Einstein's geometric theory of gravity -- Relativistic stars -- The universe -- Gravitational collapse and black holes -- Gravitational waves -- Experimental tests of general relativity -- Frontiers
Report
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