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Cryo-Electron Microscopy in Structural Biology
Cryo-electron microscopy, in combination with tomography, has emerged as a new technology for visualizing molecular structures at a resolution beyond even 1 Å. Using this technology has revealed the native molecular details of viruses, membranes, enzymes, ribosomes, and cells. This comprehensive volume brings together authoritative overviews of these methods from structural and biological perspectives. It is a must-have for researchers and graduate students, as well as those working in industry, primarily in the areas of biophysics, structural biology, crystallography, and genomics. Key Features • Focuses on the applications of cryo-EM to structural biology • Documents the importance of cryo-EM/ET approaches in studying the structural determinants of cellular organelle and membrane protein biochemistry • Reviews the applications of high-resolution structures of viruses • Emphasizes structural insights of nuclear and gene machineries • Includes a section focused entirely on the applications of cryo-EM/ET in drug discovery and therapeutic development
Nitroxides
This book covers synthesis, physicochemical studies and applications of nitroxides, showcasing the developments which have occurred in recent years.
Depression: From Psychopathology to Pharmacotherapy
Despite the availability of antidepressants for over 40 years, a substantial proportion of depressed patients do not respond adequately to treatment. Failure to respond effectively to treatment contributes to physical ill-health and psychiatric morbidity, often resulting in premature death of the depressed patient. The purpose of this volume is to consider the possible reasons for the limitations of the currently available antidepressants, to examine the advances in our understanding of the psychopathology of depression and how such knowledge may assist in the discovery of new methods of treatment. Leading international experts in this field discuss the possible underlying reasons for depression and limitations of current antidepressants. Opportunities for novel therapeutic approaches to dysfunctional circadian rhythms and mood disorders as well as current status and future perspectives for optimizing antidepressant management of depression are reviewed. This publication illustrates the breadth of the latest research and is valuable reading for psychiatrists, neuroscientists and pharmacologists.
Nanocrystalline Materials
This second edition of Nanocrystalline Materials provides updated information on the development and experimental work on the synthesis, properties, and applications of nanocrystalline materials. Nanocrystalline materials with new functionalities show great promise for use in industrial applications — such as reinforcing fillers in novel polymer composites — and substantial progress has been made in the past decade in their synthesis and processing. This book focuses primarily on 1D semiconducting oxides and carbon nanotubes, 2D graphene sheets and 0D nanoparticles (metals and inorganic semiconductors). These materials are synthesized under different compositions, shapes and structures, ...
Technological Innovation for Digitalization and Virtualization
This book constitutes the refereed proceedings of the 13th IFIP WG 5.5/SOCOLNET Advanced Doctoral Conference on Computing, Electrical and Industrial Systems, DoCEIS 2022, held in Caparica, Portugal, during June-July 2022. The 22 full papers presented were carefully reviewed and selected from 48 submissions. The papers present selected results produced in engineering doctoral programs and focus on technological innovation for industry and service systems. The papers are organized into the following topical sub-headings: Smart Systems Thinking; Cyber-physical Systems; health-related Digitalization; Electric Systems and Machines; Smart Devices; and Control and Digital Platforms.
The Attribute of Water
This book features the latest advances and future trends in water science and technology. It also discusses the scientific popularization and quantitative resolution of a variety of mysterious properties of water and ice from the perspective of hydrogen-bond cooperativity in response to stimuli such as chemical contamination, electrification, magnetification, mechanical compression, molecular undercoordination, and thermal excitation. Anomalies include the floating of ice, the Hofmeister effect in solutions, regelation of ice, slipperiness of ice, water’s tough skin, the Mpemba paradox, and the floating bridge. It also addresses the superfluidity of microchannels, hydrogen bond potentials, nanodroplet and bubble thermodynamics, quasisolidity and supersolidity, controlling superhydrophobicity–superhydrophilicity transition, and high-pressure ice formation. The target audience for this book includes students, senior scholars, engineers and practitioners in the area of physical chemistry, biology, as well as aqueous and colloid solutions.
Advances and Trends in Artificial Intelligence. From Theory to Practice
This two-volume set of LNAI 12798 and 12799 constitutes the thoroughly refereed proceedings of the 34th International Conference on Industrial, Engineering and Other Applications of Applied Intelligent Systems, IEA/AIE 2021, held virtually and in Kuala Lumpur, Malaysia, in July 2021. The 87 full papers and 19 short papers presented were carefully reviewed and selected from 145 submissions. The IEA/AIE 2021 conference will continue the tradition of emphasizing on applications of applied intelligent systems to solve real-life problems in all areas. These areas include the following: Part I, Artificial Intelligence Practices: Knowledge discovery and pattern mining; artificial intelligence and m...
Renewable Resources for Surface Coatings, Inks and Adhesives
Providing a detailed survey of renewable raw materials for paints, inks and glues, this book is ideal for researchers and practitioners working in the areas of green chemistry, industrial chemistry and sustainability. Beginning with a brief history of coatings and adhesives, this book walks the reader through the chemistry, properties, sourcing and processing of a number of renewable raw materials, including lipids, natural resins, proteins, and carbohydrates. Their use in a range of recent developments and concepts from material protection, to decorative paints and coatings, adhesives and sealants is highlighted, providing the reader with a complete and modern foundation to the field.
The Theosophist
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