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T cell specificity and Cross-reactivity – Implications in Physiology and Pathology
Conventional CD8+ and CD4+ T cells recognize antigens, presented by antigen-presenting cells in the form of short peptides loaded onto major histocompatibility complex (MHC) class I and class II molecules, through their T cell receptor (TCR). Somatic gene rearrangement of the TCR locus and randomization of TCR hyper-variable regions generate the marked diversity of TCRs. Once assembled, the heterodimeric TCR confers specificity to naïve T cells. The naïve T cell repertoire of an individual is established by selection processes in the thymus and cannot be broadened upon antigen recognition by additional somatic mutations. In humans, the estimated number of distinct TCRs in the naïve T cell...
L Assassinio Notarbartolo O Le Gesta Della Mafia
«CREDETE a me, caro signor Luraschi, se voi siete un giornalista con dei pregiudizi, venuto nella nostra Isola con dei preconcetti, la è finita; io non ho altro da aggiungere. Ma se siete un giornalista che salta la leggenda e studia l'ambiente per proprio conto, voi ritornerete al vostro giornale un difensore del siciliano trascinato per le colonne dei giornali come un delinquente nato. Qualcuno, non ricordo più chi, ha paragonato la Sicilia all'Irlanda e non ha avuto torto. In Irlanda un contadino taglia i garretti al bestiame di un landlord, ed ecco tutta la Grande Bretagna in aria come se si trattasse di un avvenimento inaudito. Il dizionario non ha più sostantivi abbastanza roventi ...
Flow Cytometry and Cell Sorting
The analysis and sorting of large numbers of cells with a fluorescence-activated cell sorter (FACS) was first achieved some 30 years ago. Since then, this technology has been rapidly developed and is used today in many laboratories. A Springer Lab Manual Review of the First Edition: "This is a most useful volume which will be a welcome addition for personal use and also for laboratories in a wide range of disciplines. Highly recommended." CYTOBIOS
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