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In the early 1980s, a few scientists started working on a Xenopus transcription factor, TFIIIA. They soon discovered a novel domain associated with zinc, and named this domain "zinc finger. " Th e number of proteins with similar zinc fingers grew quickly and these proteins are now called C2H2, Cys2His2 or classical zinc finger proteins. To date, about 24,000 C2H2 zinc finger proteins have been recognized. Approximately 700 human genes, or more than 2% of the genome, have been estimated to encode C2H2 finger proteins. From the beginning these proteins were thought to be numerous, but no one could have predicted such a huge number. Perhaps thousands of scientists are now working on C2H2 zinc f...
Nobleman sleuth Daidoji Shin returns for a brilliant new investigation deep in the Emerald Empire, in this exciting novel set in the fantastical world of Legend of the Five Rings Daidoji Shin, former louche layabout turned amateur investigator, and his long-suffering bodyguard, Kasami, are called away from the comforts of the City of the Rich Frog and into Unicorn lands to investigate a seemingly open-and-shut case of murder. But it’s never that straightforward… A condemned woman’s life is at stake, and the outcome may prevent a war between noble families. But that’s only the beginning of this mystery: Shin will come face to face with a sinister seditionist organization that could have much deeper consequences than he could imagine.
This up-to-date guide focuses on the understanding of key regulatory mechanisms governing gene expression in Escherichia coli. Studies of E. coli not only provide the first models of gene regulation, but research continues to yield different control mechanisms.
The science of biology celebrates the discovery and understanding of biological systems that already exist in nature. In parallel, the engineering of biology must learn how to make use of our understanding of the natural world to design and build new useful biological systems. ""Synthetic biology"" represents one example of recent work to engineer biological systems. This emerging field aims to replace the ad hoc process of assembling biological systems by primarily developing tools to assemble reliable-but-complex living organisms from standard components that can later be reused in new combination. The focus of this book is ""genome refactoring,"" one of several approaches to manage the co...
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