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ntegrative Pharmacology can be used to determine the multi-pharmacological effects of traditional medicines such as traditional Chinese medicine (TCM), Kampo, Sa-sang, Ayurveda, etc.). Through qualitative and quantitative pharmacokinetic-pharmacodynamic (PK-PD) correlations among multi-constituents and multi-targets, integrating chemical profiling, ADME/PK processes, molecular network calculation and resulting experimental validation, the use of Integrative Pharmacology has become widespread. The data has provided a novel paradigm to evaluate the druggability of bioactive ingredients of herbs or formulae, to decipher the pharmacological mechanisms of drug action and to screen potentially new indications for approved drugs and previously unidentified adverse events. On this basis, Integrative Pharmacology may offer an effective way to test the potential scientific basis for traditional medicines and to assess what roles of traditional medicine can and cannot play in pharmaceuticals.
It is now well known that proteases are found everywhere, in viruses and bacteria as well as in all human, animal and plant cells, and play a role in a variety of biological functions ranging from digestion, fertilization, development to senescence and death. Under physiological conditions the ability of proteases is regulated by endogenous inhibitors. However, when the activity of proteases is not regulated appropriately, disease processes can result, as seen in Alzheimer’s disease, cancer metastasis and tumor progression, inflammation and atherosclerosis. Thus it is evident that there is an absolute need for a tighter control of proteolytic activities in different cells and tissues. Aime...
Li shows readers-- from the grassroots-- a country full of energy, irony, and paradox.
The 2010 International Conference on Life System Modeling and Simulation (LSMS 2010) and the 2010 International Conference on Intelligent Computing for Sustainable Energy and Environment (ICSEE 2010) were formed to bring together researchers and practitioners in the fields of life system modeling/simulation and intelligent computing applied to worldwide sustainable energy and environmental applications. A life system is a broad concept, covering both micro and macro components ra- ing from cells, tissues and organs across to organisms and ecological niches. To c- prehend and predict the complex behavior of even a simple life system can be - tremely difficult using conventional approaches. To...
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Written with the assistance of a team of lecturers at the Shanghai University of Political Science and Law, this book is the leading reference on Chinese private international law in English. The chapters systematically cover the whole of Chinese private international law, not just questions likely to arise in commercial matters, but also in family, succession, cross-border insolvency, intellectual property, competition (antitrust), and environmental disputes. The chapters do not merely cover the traditional conflict of law areas of jurisdiction, applicable law (choice of law), and enforcement. They also look into conflict of law questions arising in arbitration and assess China's involvement in the harmonisation of private international law globally and regionally within the Belt and Road Initiative. Similarly to the Japanese and Indonesian volumes in the Series, this book presents Chinese conflict of laws through a combination of common and civil law analytical techniques and perspectives, providing readers worldwide with a more profound and comprehensive understanding of Chinese private international law.
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An updated and comprehensive history of Mao Zedong’s Land Reform Movement in China. Mao Zedong’s land reform campaigns comprise a critical moment in modern Chinese history, and were crucial to the rise of the Chinese Communist Party. In Land Wars, Brian DeMare draws on new archival research to offer an updated and comprehensive history of this attempt to fundamentally transform the countryside. Across this vast terrain loyal Maoists dispersed, intending to categorize poor farmers into prescribed social classes, and instigate a revolution that would redistribute the land. To achieve socialist utopia, the Communists imposed and performed a harsh script of peasant liberation through fierce ...