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This detailed volume presents a variety of mouse models for cancer studies, from leukemia and lymphoma models to different types of subcutaneous and orthotopic models. Models for the healing process and the assessment of the immune response after local ablative therapies are also included, as well as imaging techniques that allow for the visualization of cancer at the cellular and tissue level. The book closes with a detailed description of necropsy, which is essential for obtaining good biomaterial for translational research. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Mouse Models of Cancer: Methods and Protocols serves as an ideal guide to these controlled and reproducible model experimental systems to study different aspects of cancer biology, including prevention, development, progression, and treatment.
At present, less than 30% of researchers worldwide are women. Long-standing biases and gender stereotypes are discouraging girls and women away from science-related fields, and STEM research in particular. Science and gender equality are, however, essential to ensure sustainable development as highlighted by UNESCO. In order to change traditional mindsets, gender equality must be promoted, stereotypes defeated, and girls and women should be encouraged to pursue STEM careers. Therefore, Frontiers in Immunology is proud to offer this platform to promote the work of women scientists, across all fields of Cancer Immunity and Immunotherapy.
Delo prinaša besediloslovno analizo govorjenega diskurza. V ospredju zanimanja so načini, po katerih se v spontani neformalni konverzaciji vzpostavlja besedilna koherenca, ter analizirane okoliščine, ki vplivajo na to, ali je konverzacija koherentna ali ne. Prikazana so tudi kohezivna sredstva in načini, kako se v konverzaciji vzpostavljajo kohezivne vezi ter gradi (ko)referenčna mreža. Uporabljeni so štirje sodobni pristopi k analizi diskurza: pragmatična perspektiva, konverzacijska analiza, besediloslovje in funkcijsko jezikoslovje.