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Triple Helix Forming Oligonucleotides
Sequence-specific DNA binding ligands, amongst which triple helix forming oligonucleotides are the most efficient as yet, represent promising tools in a number of fields. One of their most promising applications is as antiviral tools: they can specifically target a viral gene, even if it is integrated into the host genome, and be used to specifically inactivate the viral gene or even destroy the cells harboring this gene. However, from science fiction to science there remains a gap; and we are at the moment on the threshold of this fascinating field. Triple Helix Forming Oligonucleotides considers the different aspects of the design and improvement, current or future, of these molecules and their structural analysis, as well as their applications, with special emphasis on the attempts to obtain biological effects of these potentially important tools. What emerges is that the current state of the research is encouraging, and that these molecules are already useful in some biotechnology applications.
Handbook of Essential Fatty Acid Biology
Internationally eminent scientists illuminate the most important scientific aspects of essential fatty acids (EFAs)-from their biochemistry to their physiological consequences in both health and illness. The distinguished contributors integrate a wide range of topics, including the basic biochemistry of EFAs and lipid metabolism, the role of EFAs in the neuronal membrane, the effects of EFAs and lipids in various diseases, and the effects of normal levels and EFA deficiencies on cognition and behavior. The book's consolidation of our knowledge of the biology and metabolism of the EFAs lays the groundwork for dramatic advances in our understanding of these ubiquitous biochemicals and their role in health and illness.
DHA
In this breakthrough book for preventive medicine, Gormley, the award-winning editor of "Better Nutrition" magazine and one of America's foremost experts on supplemental nutrition, draws on cutting-edge research from around the world to explain the benefits of DHA and other omega-3 fats. With rich insight and clear language, he traces the evolution of these studies and explains how to make DHA a beneficial part of one's diet.
The Taxation of Permanent Establishments
This book provides a comprehensive analysis of the rules governing the taxation of permanent establishments as implemented in the OECD Model Tax Convention and German national tax law. Deviations between the OECD approach and the German approach are identified and modifications to the rules as a result of the Base Erosion and Profit Shifting (BEPS) project are examined. Moreover, challenges imposed to the PE concept as a result of the digitalisation of the economy are identified and discussed. Against this background, the Pillar One Blueprint proposing a long-term solution to overcome the tax challenges arising from the digitalisation of the economy is presented and assessed against widely accepted overarching principles of tax policy.
Economics of the International Coal Trade
This book analyzes the international seaborne steam coal trade and investigates resource economics and market structures of the global coal market. It develops a model to analyze pricing structures which are based on the cost minimization principle.
Applications of Antisense Therapies to Restenosis
Restenosis, the proliferation of smooth muscle cells (SMC) that line blood vessels, often follows angioplasty. Despite advances in cardiology, restenosis continues to affect up to 40% of the over 500,000 patients who undergo angioplasty each year. Applications of Antisense Therapies to Restenosis is the first volume to address the potential of using antisense therapies to inhibit the restenosis that occurs after percutaneous transluminal angioplasty and coronary stenting. The work critically examines the application of various antisense therapies for inhibiting restenosis.
Host Defense Dysfunction in Trauma, Shock and Sepsis
This book presents a unique overview of all aspects of host defense alterations under stressful conditions. It is based on the most important contributions given at the "2nd International Congress on the Immune Consequences of Trauma, Shock, and Sepsis-Mechanisms and Therapeutic Approaches," which was held in Munich under the auspices of the most distinguished scientific societies involved in this field (Society of Critical Care Medicine, European Society of Intensive Care Medicine, Societe Internationale de Chirurgie, Surgical Infection Society, Surgical Infection Society Europe, European Society for Surgical Research, International Society for Burn Injury, American Association for the Surg...
Manual of Spine Surgery
This manual has been compiled in response to the rapid expansion of instrumented spinal surgery using minimally invasive and non-fusion techniques, with a view to meeting the needs of spinal surgeons (orthopaedic and neurosurgeons). The various open, less invasive, and minimally invasive techniques are presented step by step in a clear and instructive way with the aid of more than 600 high-quality illustrations. Careful attention is paid to all aspects vital to the success of any spinal operation: precise definition of indications and contraindications, technical and organizational factors, good operating technique, and correct preoperative preparation and positioning of the patient. This second edition of the manual takes full account of the latest developments in spinal instrumentation and implants and new surgical techniques. It is authoritative, concise, and portable – ideal for use in a fast-paced clinical setting – and will serve as a daily companion for spinal surgeons and others who care for patients with spinal disorders.
