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Molecular Targets in Oncological and Hematological Disease Management: Innovations in Precision Medicine
Targeted therapies use specific therapeutic agents that specifically target a molecule that is involved in disease progression. By targeting these specific molecules, the molecular pathway of the disease development could be modulated thus inhibiting the disease progression. By specifically targeting a molecule involved in disease development, we can overcome potential side effects, increasing the precision of the treatment. Precision medicine approaches have been particularly successful in the field of oncology, where targeted therapies have been tested and developed for specific mutations or molecules that promote tumor growth. This Research Topic is centered around the use of therapeutic ...
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Formability of Metallic Materials
After a brief introduction into crystal plasticity,the fun- damentals of crystallographic textures and plastic anisotro- py, a main topic of this book, are outlined. A large chapter is devoted to formability testing both for bulk metal and sheet metal forming. For the first time testing methods for plastic anisotropy of round bars and tubes are included. A profound survey is given of literature about yield criteria for anisotropic materials up to most recent developments and the calculation of forming limits of anisotropic sheet me- tal. Other chapters are concerned with properties of workpieces after metal forming as well as the fundamentals of the theory of plasticity and finite element simulation of metal forming processes. The book is completed by a collection of tables of international standards for formability testing and of flow curves of metals which are most commonly used in metal forming. It is addressed both to university and industrial readers.
Chess Results, 1951-1955
This comprehensive chronological reference work lists the results of men's chess competitions all over the world--individual and team matches, from 1951 through 1955--with sources. Entries record location and, when available, the group that sponsored the event. First and last names of players are included whenever possible and are standardized for easy reference. Compiled from contemporary sources such as newspapers, periodicals, tournament records and match books, this work contains 1,620 tournament crosstables and 144 match scores. It is indexed by events and by players.
Design and Manufacturing
In product development, decisions taken in design and manufacturing are considered the most influential factors for succeeding commercialisation. Product development is a complex integrated process of several steps starting from design where the market needs are identified and turned into competitive product specifications and different design concepts. In other words, design is about identifying a problem, developing solution proposals, and validating the most feasible solution with real users. Manufacturing technologies, on the other hand, help designers to make those virtual models into physical parts by transforming different types of raw materials. This book on design and manufacturing, written by a number of experts from all over the world, presents a design perspective and different manufacturing applications from various industrial sectors.
