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Stem Cells
Much of our knowledge of stem cells has been inferred from studies of remarkable few species. The ability to manipulate stem cells in “model” organisms such as the mouse and a few other vertebrate species has driven our understanding of basic biology of stem cells. The power and efficiency of studying model organisms, however, comes at a cost since a few species, obviously, do not reflect nature ́s true diversity. Unfortunately, although all multicellular organisms seem to rely on stem cells, and although this seems to be a question of key importance for understanding the evolution of animal life, little is known about stem cells in early-branching taxa. “Stem Cells: From Hydra to Man...
Advances in Aquatic Invertebrate Stem Cell Research
This publication is based upon work from COST Action ’16203 MARISTEM Stem cells of marine/aquatic invertebrates: from basic research to innovative applications’, supported by COST (European Cooperation in Science and Technology). COST (European Cooperation in Science and Technology) is a funding agency for research and innovation networks. Our Actions help connect research initiatives across Europe and enable scientists to grow their ideas by sharing them with their peers. This boosts their research, career and innovation. www.cost.eu Aquatic invertebrates represent the largest biodiversity and the widest phylogenetic radiation on Earth, with more than 2 million known species. Up until a...
Understanding Development
Using familiar examples and clear arguments, this volume offers fresh alternatives to widespread misconceptions about biological development.
Muscle Homeostasis and Regeneration
The book is a collection of original research and review articles addressing the intriguing field of the cellular and molecular players involved in muscle homeostasis and regeneration. One of the most ambitious aspirations of modern medical science is the possibility of regenerating any damaged part of the body, including skeletal muscle. This desire has prompted clinicians and researchers to search for innovative technologies aimed at replacing organs and tissues that are compromised. In this context, the papers, collected in this book, addressing a specific aspects of muscle homeostasis and regeneration under physiopathologic conditions, will help us to better understand the underlying mechanisms of muscle healing and will help to design more appropriate therapeutic approaches to improve muscle regeneration and to counteract muscle diseases.
Whole-Body Regeneration
This Open Access volume provides a comprehensive overview of the latest tools available to scientists to study the many facets of whole-body regeneration (WBR). The chapters in this book are organized into six parts. Part One provides a historical overview on the study of the WBR phenomena focusing on the primary challenges of this research. Parts Two and Three explore a series of non-vertebrate zoological contexts that provide experimental models for WBR, showing how they can be approached with cellular tools. Parts Four, Five, and Six discuss the future advancements of WBR, reporting about the cutting-edge techniques in genetics and omics used to dissect the underlying mechanisms of WBR, a...
Brill's Companion to the Philosophy of Biology
In this volume, Andrea Borghini and Elena Casetta introduce a wide spectrum of key philosophical problems related to life sciences in a neat framework and an accessible style, with a special emphasis on metaphysical issues. The volume is divided into three parts. The first addresses the two main questions stemming from life sciences: what is life, and what is the correct understanding of the theory of evolution? The second part looks at metaphysical questions concerning biological entities: environments, species, organisms, and biological individuals. The third part focuses on theoretical questions of particular ethical and political significance: sex and gender, the biotechnological revolution, and the evolution of behavior and culture. Each chapter is followed by a list of further readings.
Tutt’intorno è Francia
«Parto leggero, per il lungo viaggio sulle strade di Francia. Troverò quel che mi serve per via, e anche un po’ me stesso, perché questo libro percorre una terra che è un po’ mia, fra gente che è mia, torinese e sabaudo a pochi passi dal confine». Inizia così il lungo viaggio di Carlo Grande attraverso l’Esagono: un viaggio del cuore, alla scoperta dei cugini d’Oltralpe, sulle tracce dei grandi che ne hanno fatto la storia e di quelle figure che costituiscono patrimonio comune della cultura europea. Perché le montagne uniscono e non ostacolano, in barba agli odiosi muri moderni. Un itinerario sulle strade di Francia, al di là degli stereotipi. Dal Sud – le assolate spiagge della Costa Azzurra, rifugio di artisti e scrittori, e orgoglio occitano ancora intatto – verso il cuore profondo del Paese – la Loira dei re e di Leonardo – fino al Nord di Proust e Leblanc, tra memorie letterarie e ricordi di guerra; e poi ancora giù verso le Alpi, dove Italia e Francia si saldano indissolubilmente. Alla scoperta di un Paese che, dopotutto, amiamo sempre alla follia.
Stem Cells in Marine Organisms
Do real stem cells and stem cell lineages exist in lower organisms? Can stem cells from one organism parasitize the soma and/or the germ line of conspecifics? Can differentiated cells in marine organisms be re-programmed to regenerate tissues, organs and appendages through novel de-differentiation, transdifferentiation, or re-differentiation processes, leading to virtually all three germ layers, including the germline? The positive answers to above questions open a new avenue in stem cell research: the biology of stem cells in marine organisms. It is therefore unfortunate that while the literature on stem cell from terrestrial organisms is rich and expanding at an exponential rate, investiga...
MorphoEvoDevo: A Multilevel Approach to Elucidate the Evolution of Metazoan Organ Systems
Analyzing animal development in a comparative framework provides a unique window into evolutionary history. With a long tradition that dates back to iconic 19th-century zoologists such as Ernst Haeckel and Charles Darwin, Evolutionary Developmental Biology is firmly rooted in morphological research. While studies using a classical model system approach have resulted in considerable methodological progress, in particular by establishing molecular genetic tools to tackle questions surrounding animal development, it quickly became obvious that a broad comparative dataset involving as many taxa as possible is necessary for sound evolutionary inferences. Thus, today’s EvoDevo embraces morphological, molecular, and experimental procedures, interpreted in a phylogenetic framework, in order to answer key questions that revolve around the evolution of animal cell types, organ systems, and, ultimately, entire species.
