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Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy
  • Language: en
  • Pages: 563

Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy

Taken together the data presented in this review, and work by many other investigators, support the notion that DNA excision repair is important in a tumor cell's resistance to platinum compounds. Inhibition of this repair system by combination chemotherapy with the excision repair inhibitors HU and Ara-C produces synergistic cell kills and increased levels and persistance of DNA interstrand crosslinks. The studies with cis-DDP and ~-DDP in combination with UV induced thymine dimers suggest that there may be competition for DNA repair enzymes between the dimer and the platinum lesion. Whether the competing lesion is an intrastrand crosslink, interstrand crosslink, or platinum monoadduct (or ...

Research Awards Index
  • Language: en
  • Pages: 712

Research Awards Index

  • Type: Book
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  • Published: 1985
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  • Publisher: Unknown

None

Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy
  • Language: en
  • Pages: 381

Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy

Cisplatin, the first member of the family of platinum-containing chemotherapeutic agents, was discovered by Barnett Rosenberg in 1965 and approved by the FDA for marketing in 1978. After 30 years of use in the clinic, cisplatin remains a central element of many treatment regimens. Cisplatin is still an irreplaceable component of a regimen that produces high cure rates in even advanced nonseminomatous germ-cell cancers, and is widely used in the treatment of ovarian cancers and other gynecologic cancers, head and neck, and numerous other tumor types. The development of carboplatin has reduced some of the adverse events associated with cisplatin treatment, and the introduction of the DACH plat...

Cancer Treatment Reports
  • Language: en
  • Pages: 706

Cancer Treatment Reports

  • Type: Book
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  • Published: 1987
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  • Publisher: Unknown

None

Journal of the National Cancer Institute
  • Language: en
  • Pages: 1054

Journal of the National Cancer Institute

  • Type: Book
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  • Published: 2000
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  • Publisher: Unknown

None

Biomedical Index to PHS-supported Research
  • Language: en
  • Pages: 812

Biomedical Index to PHS-supported Research

  • Type: Book
  • -
  • Published: 1990
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  • Publisher: Unknown

None

Journal of the Sons of Temperance
  • Language: en
  • Pages: 728

Journal of the Sons of Temperance

  • Type: Book
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  • Published: 1892
  • -
  • Publisher: Unknown

None

Biomedical Index to PHS-supported Research: Project number listing, investigator listing
  • Language: en
  • Pages: 968

Biomedical Index to PHS-supported Research: Project number listing, investigator listing

  • Type: Book
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  • Published: 1989
  • -
  • Publisher: Unknown

None

Cancer Drug Resistance
  • Language: en
  • Pages: 611

Cancer Drug Resistance

Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.

Current Catalog
  • Language: en
  • Pages: 1712

Current Catalog

  • Type: Book
  • -
  • Published: 1985
  • -
  • Publisher: Unknown

First multi-year cumulation covers six years: 1965-70.