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Inflammation of the CNS can have devastating, long-lived, and in some cases fatal consequences for patients. The stimuli that can induce CNS inflammation are diverse, and include infectious agents, autoimmune responses against CNS-expressed antigens, and sterile inflammation following ischemia or traumatic injury. In these conditions, cells of the immune system play central roles in promulgation and resolution of the inflammatory response. However, the immunological mechanisms at work in these diverse responses differ according to the nature of the response. Our understanding of the actions of immune cells in the CNS has been restricted by the difficulty in visualising leukocytes as they und...
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In its statutory authority (National Science Foundation Act of 1950, as amended), the NSF is directed to both initiate and support basic scientific research. In its Ecology Program, one mode of initiating research is to en courage the development of new ideas through advisory workshops. The NSF is specifically directed to strengthen our nation's research potential. In addition, stimulating new approaches to research will continue to be prominent in the coming years as federal attention is given to increasing the innovativeness and competitiveness of the U. S. in science and engineering. A decision to initiate a workshop does not arise de novo in the Ecology Program. Rather, it emerges from p...