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Genomics in Endocrinology
Genomics in Endocrinology focuses on exciting new advances in endocrinology resulting from DNA microarray studies and includes a comprehensive introduction to the use of DNA microarrays in endocrinology. The text provides the basis for further understanding of the usefulness of microarray analyses in endocrinology research. Topics discussed include the methodology of DNA microarrays and general methods for the analysis of microarray data.
HIV, Perinatal Infections, and Therapy
Papers on the role of the placenta in HIV and other perinatal infections. Proceedings from the 12th Rochester Trophoblast Conference, held in Autumn 1992 in Rochester, New York. The first part of the book addresses the role of the placenta in the transmission of the HIV infection, the central focus of the Conference. Other pre-natal infections, including CMV, Vaccina, Parvovirus, Syphillis, and Herpes Simplex, are then considered, and their implications for perinatal health investigated. The importance of cell regulation is alsodiscussed, exploring the controlling factors which modulate the placental cell membrane and metabolic functions, such as genetic imprinting; the regulation of arachidonic acid cascade; autocrine role for human chorionic gonadotropin; biochemical screening for Down's Syndrome; the role of growth factors and interferon; the autoregulation of gas exchange; and the role of uterine cytokines. HENRY THIEDE is Professor of Obstetrics and Gynecology at the University of Rochester. RICHARD K. MILLERteaches in the University of Rochester Medical Center.
Prolactin Secretion: A Multidisciplinary Approach
Prolactin Secretion: A Multidisciplinary Approach covers the proceedings of the 1982 symposium on the frontiers and perspective of prolactin secretion through a multidisciplinary approach, convened in Nabor Carrillo Hall of the Natural University of Mexico. The symposium represents a genuine interdisciplinary effort to provide insights into the complexities of prolactin. Separating 24 manuscripts into chapters, this book first discusses studies on the molecular evolution of prolactin (PRL) and the related growth hormones and placental lactogens and the relevance of these studies for biological research on PRL, with particular emphasis on PRL secretion. Significant topics on the physiology, b...
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Trophoblast Cells
Trophoblast cells coordinate the activities of maternal and embryonic tissues by secreting hormones, cytokines, and various growth factors that selectively and specifically gain access to maternal and embryonic compartments. Abnormalities associated with trophoblast cell growth, differentiation, or function result in impaired embryonic development. Understanding the complexities of the trophoblast cell signaling system was the focus of the Serono Symposia, USA conference entitled Tropho blast Cells: Pathways for Maternal-Embryonic Communication, held August 6-9, 1992, in Las Vegas, Nevada. The conference was designed to provide a forum for morphologists, cell biologists, endocrinologists, an...
Molecular and Cellular Pediatric Endocrinology
Stuart Handwerger, MD and a distinguished panel of clinicians and experts review the most significant recent developments in molecular and cellular biology, powerful advances that have produced new diagnostic methods and improved treatments for many pediatric endocrine diseases. Topics range from the growth hormone/prolactin/placental lactogen gene family and their regulation of growth, to steroid hormones, sexual development, and mineral corticoid action. Additional chapters examine the pathophysiology of insulin-dependent diabetes mellitus, the molecular genetics of thyroid cancer, the molecular basis of hypophosphatemic rickets, and inherited diabetes insipidus. Molecular and Cellular Pediatric Endocrinology offers today's clinicians and researchers not only the latest findings on endocrine diseases in their pediatric manifestations, but also highly practical insights into today's cutting-edge diagnostics, treatment strategies, and powerful new therapeutics.
Growth Hormone Secretagogues
The traditional concept of a neuroendocrine mechanism for regulation of growth hormone (GH) secretion is based in large part on the work of Roger Guillemin. The work of Dr. Guillemin, who was awarded the 1977 Nobel Prize in Physiology and Medicine, supported the view that quantita tive change in GH secretion was the net result of pituitary stimulation and inhibition by the hypothalamic neurohormones, GH releasing hormone (GHRH), and somatostatin (somatotropin release inhibiting factor; SRIF), respectively. During the 1970s, another endocrine research pioneer, Dr. Cyril Bowers, discovered that structural modification of enkephalin re sulted in a family of peptides with GH releasing properties...
Androgens in Health and Disease
Authoritative researchers and clinicians review our latest understanding of andrology in both basic science and clinical medicine. Topics range from explaining the biology of androgens-from several different perspectives-to illuminating their role in the development and modulation of physiologic systems. Authors demonstrate in a number of cases that testosterone can be a useful adjunct to the treatment of a variety of disease states. Other chapters consider important topics such as androgens use in athletes, the potential of androgens to improve physical function and quality of life in older men, and androgens as potential male contraceptives.
