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Rational Design of Stable Protein Formulations
Recombinant proteins and polypeptides continue to be the most important class of biotechnology-derived agents in today's pharmaceutical industry. Over the past few years, our fundamental understanding of how proteins degrade and how stabilizing agents work has made it possible to approach formulation of protein pharmaceuticals from a much more rational point of view. This book describes the current level of understanding of protein instability and the strategies for stabilizing proteins under a variety of stressful conditions.
Formulation, Characterization, and Stability of Protein Drugs
Leading scientists offer detailed profiles of ten protein drugs currently in development. The case histories of these important new compounds are described from the perspective of their formulation, characterization, and stability. This ready reference also features recent data and an abundance of previously unpublished information. The in-depth coverage includes a highly useful compendium of degradation sites occurring in over 70 proteins. An invaluable aid in the rapid identification of potential `hot spots' in proteins, this accessible compilation allows for inspection of the protein's primary structure and preparation of a hydroflex plot.
Frontiers in Bioprocesssing
The goal of Frontiers in Bioprocessing is twofold. First, it provides an in-depth discussion of recent developments in bioprocessing. Second, it focuses on the critical assessment of the potential of newer processing and separation techniques, including the concepts of overall process integration. This book intends to stimulate interactions among participants from various disciplinary backgrounds. It includes such topics as fermentation research, process control and measurement technology, and separation and purification in downstream processing. Those who will find this publication particularly of interest are bioengineers, biotechnologists, microbiologists, chemical engineers, as well as those studying these fields.
Green Techniques for Organic Synthesis and Medicinal Chemistry
An updated overview of the rapidly developing field of green techniques for organic synthesis and medicinal chemistry Green chemistry remains a high priority in modern organic synthesis and pharmaceutical R&D, with important environmental and economic implications. This book presents comprehensive coverage of green chemistry techniques for organic and medicinal chemistry applications, summarizing the available new technologies, analyzing each technique’s features and green chemistry characteristics, and providing examples to demonstrate applications for green organic synthesis and medicinal chemistry. The extensively revised edition of Green Techniques for Organic Synthesis and Medicinal C...
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