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This book examines the biological aspects of bile acid analysis and their clinical applications, providing readers with an overview of cutting-edge discussions on Bile Acid research and diseases. It begins with detailed discussions on the biological aspects of bile acid, with chapters examining bile acid from various perspectives, from its metabolism to its use in therapeutic agents. Subsequent chapters focus on diseases involving bile acid abnormalities, and specific applications are addressed concerning gallstones, cholestatic liver disease, NAFLD/NASH, hepatitis, pancreatitis, esophageal cancer and colon cancer. In keeping with the book’s integrated approach, the Editor has gathered a broad range of eminent scholars and practitioners to provide a comprehensive review of modern bile acid research. The book offers clinical physicians, basic researchers and postgraduate students essential insights into cutting-edge research and paves the way for further research.
Designed as a first-stop reference for researchers and professionals in toxicology, pharmacology and medicine, this handbook is the very first to tie together the knowledge from many disciplines that has so far been available only from widely dispersed sources in the primary literature. As such, it presents the complete picture on what is currently known about endogenous toxins, including their generation, mode of action, resulting disease condition, and available countermeasures. Clearly divided into four parts, the first systematically covers important toxic molecule species, including metabolic intermediates and reactive oxygen species. The second discusses the role of genetically determi...
This text uses a case-study approach to present the fundamentals of biochemistry and molecular biology in the context of human disease to students who will be involved in patient care. The 32 cases, carefully selected to cover common diseases and important principles, are supplemented by clinical descriptions of each disease and a comprehensive discussion of the underlying pathophysiological mechanisms and associated enzymatic and chemical alterations in tissues and body fluids. The Second Edition differs from its predecessor in several respects. It features seven new chapters on diseases not covered before. The Biochemical Perspectives section of each chapter has been expanded to include pe...
This comprehensive book presents the latest evidence-based data on pancreatobiliary malignancies, including the epidemiology, examination, treatment and endoscopic management. It explores a range of topics, such as risk factors, detection strategies, and novel treatment approaches like precision medicine and immunotherapy. Although there have been rapid improvements in the management of these diseases, the survival period has not yet reached a satisfactory level. This book will help those doctors needing to share the latest information with the patients and their families. It provides a wealth of practical information to help surgeons, endoscopists and oncologists as well as physicians, basic researchers and professionals at medical device and pharmaceutical companies broaden their understanding of the current treatment and management strategies for pancreatobiliary malignancies.
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Autoimmune liver disease is defined as immune-mediated chronic liver disease of unknown etiology. The forms of autoimmune liver disease include autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitits and an overlapping syndrome known as autoimmune cholangitis. These diseases were once considered to be rare. However, incidence of these diseases has increased with advanced of diagnostic techniques. During the past ten years, we have made enormous progress in understanding autoimmune mechanisms. Furthermore, new clinical and epidemiological studies have provided information that has changed our concept of autoimmune liver disease. This symposium was indeed a success due to the quality presentations by active researchers in the world.