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Leukotrienes
In the two decades since the elusive "slow reacting substance of anaphylaxis" (SRS-A) was identified as a product of the action of the 5-lipoxygenase enzyme on arachidonic acid, it has been well established that the leukotrienes are key mediators of both alIergy and inflammation. Their release by alIergen or other challenge has been demonstrated in the lungs of asthmatic subjects, and measurement of urinary leukotriene concentrations in such patients has been shown to be a valuable, non invasive indicator. Significant progress has been made towards the characterization of the leukotriene receptor subtypes, exemplified by the cloning of the LTB4 receptor earlier this year. Coupled with this t...
Leukotrienes as Mediators of Asthma and Inflammation
This volume presents the work of distinguished investigators who have conducted major studies on the role of eicosanoids in inflammation. The book provides an informative appraisal of the current state of the art in leukotriene and inflammation research, integrating new basic science concepts and clinical findings. The primary focus of the book is on the evidence that leukotrienes represent a group of mediators that contribute significantly to the pathobiology of asthma and play a role in other inflammatory disorders. The information presented in this volume is of vital importance to pharmacologists, biochemists, and physiologists, as well as to clinicians treating patients with asthma and other inflammatory diseases.
Leukotrienes as Mediators of Asthma and Inflammation
This volume presents the work of distinguished investigators who have conducted major studies on the role of eicosanoids in inflammation. The book provides an informative appraisal of the current state of the art in leukotriene and inflammation research, integrating new basic science concepts and clinical findings. The primary focus of the book is on the evidence that leukotrienes represent a group of mediators that contribute significantly to the pathobiology of asthma and play a role in other inflammatory disorders. The information presented in this volume is of vital importance to pharmacologists, biochemists, and physiologists, as well as to clinicians treating patients with asthma and other inflammatory diseases.
Leukotrienes as Mediators of Asthma and Inflammation
This volume presents the work of distinguished investigators who have conducted major studies on the role of eicosanoids in inflammation. The book provides an informative appraisal of the current state of the art in leukotriene and inflammation research, integrating new basic science concepts and clinical findings. The primary focus of the book is on the evidence that leukotrienes represent a group of mediators that contribute significantly to the pathobiology of asthma and play a role in other inflammatory disorders. The information presented in this volume is of vital importance to pharmacologists, biochemists, and physiologists, as well as to clinicians treating patients with asthma and other inflammatory diseases.
Five-Lipoxygenase Products in Asthma
Five-Lipoxygenase Products in Asthma offers an authoritative examination of the biochemistry, basic pharmacology, and clinical pharmacology of the leukotrienes with special emphasis on their role in asthma. A critical reference for every asthma researcher and clinician, Five-Lipoxygenase Products in Asthma highlights agents and products of the 5-LO pathway and its relationship to other pathways explores the enzymology of the 5-LO pathway with focus on leukotriene transport, degradation, and excretion details the role of protein identification in the 5-LO pathway describes human cell types that produce leukotrienes and their activation outlines pharmacological and binding study evidence for l...
