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Progress in Medicinal Chemistry
Appropriate selection of biochemical targets is one of the most important drivers of cost effectiveness in the discovery of new medicines. Despite the many advances in genetics, genomics and systems biology, ‘validation’ of a target is not achieved until therapeutic efficacy is demonstrated by a drug candidate. Volume 46 of this series reviews the medicinal chemistry aimed at six diverse targets from which important new medicines are emerging: * HIV integrase (discovery of the first-in-class inhibitor drug raltegravir)* 11-beta-Hydroxysteroid dehydrogenase (new approach to glucocorticoid regulation)* Nicotinic a7 choline receptor (agonists and positive allosteric modulators). * Bradykinin receptor (new approach to pain therapy)* Histone deacetylase (new drugs for cancer)* 5-HT2c receptor modulators (various CNS indications) *Presents the latest research in the field of drug discovery *Publishes on an annual basis to bring you the most innovative updates in medicinal chemistry *Available as an online resource via ScienceDirect
Soft Material-Enabled Electronics for Medicine, Healthcare, and Human-Machine Interfaces
Soft material-enabled electronics offer distinct advantage, over conventional rigid and bulky devices, for numerous wearable and implantable applications. Soft materials allow for seamless integration with skin and tissues due to enhanced mechanical flexibility and stretchability. Wearable devices, such as sensors, offer continuous, real-time monitoring of biosignals and movements, which can be applied in rehabilitation and diagnostics, among other applications. Soft implantable electronics offer similar functionalities, but with improved compatibility with human tissues. Biodegradable soft implantable electronics are also being developed for transient monitoring, such as in the weeks following surgery. To further advance soft electronics, materials, integration strategies, and fabrication techniques are being developed. This paper reviews recent progress in these areas, toward the development of soft material-enabled electronics for medicine, healthcare, and human-machine interfaces.
A History Of Korea
First published in 1996. Always there are hills in the distance, backed by mountains, wreathed in mist, and always the sound of water. These are the things that have inspired the Korea’s poets and artists and haunt the dreams of its exiles. An eastern backbone of sharp mountains has ribs that run westward and from these wooded hills flow the water that trickles through the rice fields. Climatic maps show it to be at the centre of a small area that is almost unique in its combination of cold dry winters and hot rainy summers. Most of its plants and animals are common to the temperate zone of the Northern Hemisphere but they are tested almost to destruction by seasonal alternations of Siberian cold and summer monsoons. In May the brown desert of winter begins to shimmer in a delicate veil of green which grows into a summer jungle and dies with glory in a long warm autumn of red and gold. About 600 miles in length and 150-200 miles wide, it reaches out from the mainland like an oriental Italy, with China embracing it to the north and west and Japan only 100 miles away to the south and east. This book illuminates the reader about the history of Korea.
Flexible and Stretchable Medical Devices
The book introduces flexible and stretchable wearable electronic systems and covers in detail the technologies and materials required for healthcare and medical applications. A team of excellent authors gives an overview of currently available flexible devices and thoroughly describes their physical mechanisms that enable sensing human conditions. In dedicated chapters, crucial components needed to realize flexible and wearable devices are discussed which include transistors and sensors and deal with memory, data handling and display. Additionally, suitable power sources based on photovoltaics, thermoelectric energy and supercapacitors are reviewed. A special chapter treats implantable flexible sensors for neural recording. The book editor concludes with a perspective on this rapidly developing field which is expected to have a great impact on healthcare in the 21st century.
Smart and Sustainable Intelligent Systems
The world is experiencing an unprecedented period of change and growth through all the electronic and technilogical developments and everyone on the planet has been impacted. What was once ‘science fiction’, today it is a reality. This book explores the world of many of once unthinkable advancements by explaining current technologies in great detail. Each chapter focuses on a different aspect - Machine Vision, Pattern Analysis and Image Processing - Advanced Trends in Computational Intelligence and Data Analytics - Futuristic Communication Technologies - Disruptive Technologies for Future Sustainability. The chapters include the list of topics that spans all the areas of smart intelligent systems and computing such as: Data Mining with Soft Computing, Evolutionary Computing, Quantum Computing, Expert Systems, Next Generation Communication, Blockchain and Trust Management, Intelligent Biometrics, Multi-Valued Logical Systems, Cloud Computing and security etc. An extensive list of bibliographic references at the end of each chapter guides the reader to probe further into application area of interest to him/her.
Modern NMR Approaches to the Structure Elucidation of Natural Products
The Ghanian plant Cryptolepis sanguinolenta is the source of a series of fascinating indoloquinoline alkaloids. The most unusual member of this alkaloid series was initially proposed to be a spiro nonacyclic structure, named cryptospirolepine, and was elucidated in 1993 based on the technologies available at that time. There were, however, several annoying attributes to the structure that bothered analysts for the ensuing 22 years. During the two decades that followed the initial work there have been enormous developments in NMR technology. Using new experimental approaches, specifically homodecoupled 1,1- and 1,n-HD-ADEQUATE NMR experiments developed in 2014, the structure of only a 700 µg...
Silicon Nanomembranes
Edited by the leaders in the fi eld, with chapters from highly renowned international researchers, this is the fi rst coherent overview of the latest in silicon nanomembrane research. As such, it focuses on the fundamental and applied aspects of silicon nanomembranes, ranging from synthesis and manipulation to manufacturing, device integration and system level applications, including uses in bio-integrated electronics, three-dimensional integrated photonics, solar cells, and transient electronics. The first part describes in detail the fundamental physics and materials science involved, as well as synthetic approaches and assembly and manufacturing strategies, while the second covers the wide range of device applications and system level demonstrators already achieved, with examples taken from electronics and photonics and from biomedicine and energy.
Physics and Technology of High-k Gate Dielectrics 4
This issue covers, in detail, all aspects of the physics and the technology of high dielectric constant gate stacks, including high mobility substrates, high dielectric constant materials, processing, metals for gate electrodes, interfaces, physical, chemical, and electrical characterization, gate stack reliability, and DRAM and non-volatile memories.
Green Materials for Electronics
Combining the materials science, technological, and device aspects of organic bioelectronics based on green materials, this is the first overview of the emerging concepts involving fabrication techniques for sustainable electronics with low energy and material consumption. With contributions from top-notch editors and authors, in one focus, the book covers a collection of natural materials suited for electronics applications such as paper, silk, melanin, DNA and nucleobases, resins, gums, saccharides, cellulose, gelatine and peptides. In another thrust, the book focuses on device fabrication based on these materials, including processing aspects, and applications such as sensors, signal transducers, transient, implantable and digestible electronics. With its interdisciplinary approach this text will appeal to the chemistry, physics, materials science, and engineering communities.
