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The Immunology of Sepsis – Understanding Host Susceptibility, Pathogenesis of Disease, and Avenues for Future Treatment
We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.
Evolving Concepts in Sepsis and Septic Shock
Much research over the past 30 to 40 years has shown that the inflammatory response, while critical for host defense during microbial infection, may itself play a central role in the pathogenesis of sepsis. Although key mediators responsible for this injury have been identified, efforts clinically to augment our conventional antimicrobial and supportive therapies during sepsis with agents modulating the inflammatory response have been unsuccessful. As a result, the mortality associated with this lethal syndrome, especially when complicated by shock, has remained persistently high. Unfortunately, during this same period of time, the incidence of sepsis has accelerated as other fields of medicine have relied increasingly on therapies that predispose to infection. While frustrating, overall this experience in the field of sepsis has not been without value. Most importantly, it has helped define on several different levels the complexity of the septic patient. Recognizing and addressing this complexity as discussed by each of the contributors to Evolving Concepts in Sepsis and Septic Shock may now provide new inroads into the treatment of sepsis.
The MIF Handbook
The role of the cytokine, macrophage migration inhibitory factor (MIF), in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well established. The aim of this handbook is to provide an authoritative volume covering all aspects of MIF, from basic molecular biology to structure-function relationships, pathophysiology, genetics, and drug development. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, cardiac physiology, and neurodevelopment. MIF's molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. Unique structural features of the protein, such as an intrinsic catalytic activity, and the continuing elucidation of its receptor-dependent mechanism of action offer attractive opportunities for therapeutic intervention. This volume will provide a comprehensive synthesis of the state of the art of MIF science.
Figures of Chance I
Figures of Chance I: Chance in Literature and the Arts (16th–21st Centuries) proposes a transhistorical analysis that will serve as a reference work on the evolution of literary and artistic representations of chance and contingency. Alongside its multidisciplinary companion volume (Figures of Chance II), it considers how the projective and predictive capacity of societies is shaped by representations and cultural models of a reality that is understood, to varying degrees, to be contingent, unpredictable, or chaotic. Giving special emphasis to the French context while also developing broad cross-cultural comparisons, this volume examines the dialogue between evolving conceptions and changing representations of chance, from Renaissance figures of Fortune to the data-driven world of the present. Written by recognized specialists of each of the periods studied, it identifies and historicizes the main fictional and factual modes of portraying, narrating, and comprehending chance in the West.
Fourth International Congress on Information and Communication Technology
The second volume of this book includes selected high-quality research papers presented at the Fourth International Congress on Information and Communication Technology, which was held at Brunel University, London, on February 27–28, 2019. It discusses emerging topics pertaining to information and communication technology (ICT) for managerial applications, e-governance, e-agriculture, e-education and computing technologies, the Internet of Things (IoT), and e-mining. Written by respected experts and researchers actively working in ICT, the book offers a valuable resource, especially for researchers who are newcomers to the field.
Proceedings of International Conference on Communication and Computational Technologies
This book gathers selected papers presented at 3rd International Conference on Communication and Computational Technologies (ICCCT 2021), jointly organized in virtual format by Rajasthan Institute of Engineering and Technology, Jaipur and Rajasthan Technical University Kota in association with Soft Computing Research Society, during 27–28 February 2021. The volume is a collection of state-of-the-art research work in the cutting-edge technologies related to communication and intelligent systems. The topics covered are algorithms and applications of intelligent systems, informatics and applications, and communication and control systems.
Jean Grave and the Networks of French Anarchism, 1854-1939
This biography charts the life and fascinating long militant career of the French anarchist journalist, editor, theorist, writer, campaigner and educator Jean Grave (1854-1939), from the run up to the 1871 Paris Commune to the eve of the Second World War. Through Grave, it explores the history of the French and international anarchist communist movement over seven decades: its “heroic period” (1880-1890s), shaken by terrorist violence and intense repression, the emergence of syndicalism, national and international solidarity campaigns, the divisions over the First World War, and post-war division and relegation. Through Grave, a “sedentary transnationalist,” the study investigates the networked and transnational organisation of the anarchist movement, addressing the paradox of Grave’s international influence alongside his deep rootedness in Paris by emphasizing the movement’s global print culture and staggering circulations.
The Documentary Imagination in Twentieth-Century French Literature
Studying works by authors including Gide, Breton, Aragon, Yourcenar, Duras, and Modiano, this volume re-thinks twentieth-century French literature and engages with the question of distinctions between the factual and the fictional.
