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The volatile anesthetics continue to be one of the most mysterious yet commonly used class of drugs in medical practice today. A prominent and troublesome side effect of volatile anesthetics is their ability to alter hemodynamics. This arises from two diverse but interrelated phenomena, depression of cardiac contractility and dilation of the vasculature. These effects of volatile anesthetics on cardiac and smooth muscle plus the action of volatile anesthetics on skeletal muscle in the malignant hyperthermic syndrome have led to concern about the interaction of volatile anesthetics (and other anesthetic agents) with calcium metabolism in the muscle cell. Many of the phenomena caused by anesth...
Each issue lists papers published during the preceding year.
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This important collection of essays is a synthesis of foundational studies in Bayesian decision theory and statistics. An overarching topic of the collection is understanding how the norms for Bayesian decision making should apply in settings with more than one rational decision maker and then tracing out some of the consequences of this turn for Bayesian statistics. The volume will be particularly valuable to philosophers concerned with decision theory, probability, and statistics, statisticians, mathematicians, and economists.
Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Volume 31 deals with the mechanisms of anesthetic actions under normal conditions as well as pathophysiologic states.Covers anesthetics and cardiac functionAddresses disorders of the cardiovascular system and associated diseasesExplains therapeutic and pathophysiological implicationsDetails reflex regulation of peripheral circulationIncludes full descriptions of the latest methodologiesWritten by internationally recognized experts in the field of anesthesia research
How to conduct clinical trials in an ethical and scientificallyresponsible manner This book presents a methodology for clinical trials that producesimproved health outcomes for patients while obtaining sound andunambiguous scientific data. It centers around a real-world testcase--involving a treatment for hypertension after open heartsurgery--and explains how to use Bayesian methods to accommodateboth ethical and scientific imperatives. The book grew out of the direct involvement in the project by adiverse group of experts in medicine, statistics, philosophy, andthe law. Not only do they contribute essays on the scientific,technological, legal, and ethical aspects of clinical trials, butthey...
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First multi-year cumulation covers six years: 1965-70.