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The Antidote
In 1989, the charismatic Joshua Boger left Merck, then America's most admired business, to found a drug company that would challenge industry giants and transform health care. Journalist Barry Werth described the company's tumultuous early days during the AIDS crisis in The Billion-Dollar Molecule, a celebrated classic of science and business journalism. Now he returns to tell the story of Vertex's bold endurance and eventual success. The pharmaceutical business is America's toughest and one of its most profitable. It's riskier and more rigorous at just about every stage than any other business, from the towering biological uncertainties inherent in its mission to treat disease; to the 30-to-1 failure rate in bringing out a successful medicine; to the multibillion-dollar cost of ramping up a successful product; to operating in the world's most regulated industry, matched only by nuclear power. Werth captures the full scope of Vertex's 25-year drive to deliver breakthrough medicines.--From publisher description.
Designing Data-Intensive Applications
Data is at the center of many challenges in system design today. Difficult issues need to be figured out, such as scalability, consistency, reliability, efficiency, and maintainability. In addition, we have an overwhelming variety of tools, including relational databases, NoSQL datastores, stream or batch processors, and message brokers. What are the right choices for your application? How do you make sense of all these buzzwords? In this practical and comprehensive guide, author Martin Kleppmann helps you navigate this diverse landscape by examining the pros and cons of various technologies for processing and storing data. Software keeps changing, but the fundamental principles remain the s...
A Little Life
Moving to New York to pursue creative ambitions, four former classmates share decades marked by love, loss, addiction, and haunting elements from a brutal childhood.
Dragon Age: The Masked Empire Deluxe Edition
Empress Celene of Orlais rose to the throne of the most powerful nation in Thedas through wisdom, wit, and ruthless manipulation. Now the empire she has guided into an age of enlightenment is threatened from within by imminent war between the templars and the mages, even as rebellion stirs among the downtrodden elves. To save Orlais, Celene must keep her hold on the throne by any means necessary. At her heels are Grand Duke Gaspard, an Orlesian chevalier who believes the kingdom deserves a new, stronger leader; and Briala, Celene's handmaid, spymaster, and lover, who wants nothing more than to fight for her people--the elves. Alliances are forged and promises broken as Celene and Gaspard battle for the throne. In the end, however, the elves, hidden and starving, may decide the fate of the masked empire themselves. This deluxe edition features twenty-four brand new illustrations by Stefano Martino, Álvaro Sarraseca, Andres Ponce, and German Ponce in an intricately designed, foil stamped hardcover!
Worth Any Price
What is love worth when you can buy anything you want? Hot new karate instructor? Yes, please! Rick is delicious enough to melt Amber Lovett’s common sense into a sticky puddle of goo. Oh, that dimple! But it’s his kindness toward her son that makes him irresistible enough to forget her no-relationships rule and risk her heart on another try at love. Except he’s not who she thought he was. No, he’s everything she’s sworn to stay far away from. Rich. Powerful. Ruthless. She made that mistake once before and lost everything. Never again. Investment guru Richard Beaumont just jettisoned one bad relationship. He’s not looking for another. Especially not with a struggling single mom, ...
You Are Worth It
Do you sometimes reduce the price of your treatments in your head because you feel your patients cannot afford them? Does talking of money in your surgery make you feel uncomfortable? Are you worried about quoting a price due to the fear you might get a negative response from your patient? Do you feel your services are worth more than you get paid for them? If you have answered yes to any of these questions, then I promise you will enjoy reading this book. This book reveals information on exactly how to deal with this problem. As far as I am aware, the contents are not taught at any dentistry school. While certain elements of pricing may have been touched on by dental coaches, theyll have ba...
Four Legs Move My Soul
An illuminating look at the story behind the success of one of the best dressage riders in the world. German Olympian Isabell Werth has six Olympic gold medals and scores of championship titles to her name—there are few her equal on paper. But an equestrian’s success is wholly dependent on the relationship she has with her athletic partner―her horse―and Werth’s astounding accomplishments would not have been possible without her unique approach to working with the animals she’s loved since childhood. Even as a little girl, growing up on a farm on the Lower Rhine, it was clear that Werth possessed an extraordinary gift for empathizing with horses and foreseeing how they were likely...
Figure Drawing For All It's Worth
Andrew Loomis (1892-1959) is revered amongst artists - including comics superstar Alex Ross - for his mastery of drawing. His first book, Fun With a Pencil, published in 1939 is a wonderfully crafted and engaging introduction to drawing, cartooning, and capturing the essence of a subject all while having fun. With delightful step-by-step instruction from Professor Blook, Loomis s charming alter ego on the page. Andrew Loomis was born in 1892. After studying art he moved to Chicago, eventually opening his own studio, working in editorial and advertising for most of the top clients at the time including Kellogg s, Coca Cola, Lucky Strike and more. He also became renowned as an art teacher and his instructional books on realist illustration and art are acclaimed classics in the field. He died in 1959.
Modern Vim
Turn Vim into a full-blown development environment using Vim 8's new features and this sequel to the beloved bestseller Practical Vim. Integrate your editor with tools for building, testing, linting, indexing, and searching your codebase. Discover the future of Vim with Neovim: a fork of Vim that includes a built-in terminal emulator that will transform your workflow. Whether you choose to switch to Neovim or stick with Vim 8, you'll be a better developer. A serious tool for programmers and web developers, no other text editor comes close to Vim for speed and efficiency. Make Vim the centerpiece of a Unix-based IDE as you discover new ways to work with Vim 8 and Neovim in more than 20 hands-...
Worth Any Cost
You are cordially invited to the wedding of the decade. Adam Drake and Emilia Kimberly Strong have chosen a date to solidify their love in the bonds of matrimony. Join them on their exotic destination wedding. Visit with their friends and loved ones. But hold the champagne toast. Fate has a few last tests for our couple on their way to the altar. Natural 20 or natural disaster?
