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Join journalist Barry Werth as he pulls back the curtain on Vertex, a start-up pharmaceutical company, and witness firsthand the intense drama being played out in the pioneering and hugely profitable field of drug research. Founded by Joshua Boger, a dynamic Harvard- and Merck-trained scientific whiz kid, Vertex is dedicated to designing—atom by atom—both a new life-saving immunosuppressant drug, and a drug to combat the virus that causes AIDS. You will be hooked from start to finish, as you go from the labs, where obsessive, fiercely competitive scientists struggle for a breakthrough, to Wall Street, where the wheeling and dealing takes on a life of its own, as Boger courts investors and finally decides to take Vertex public. Here is a fascinating no-holds-barred account of the business of science, which includes an updated epilogue about the most recent developments in the quest for a drug to cure AIDS.
In 1989, the charismatic Joshua Boger left Merck, then America's most admired business, to found a drug company that would challenge industry giants and transform health care. Journalist Barry Werth described the company's tumultuous early days during the AIDS crisis in The Billion-Dollar Molecule, a celebrated classic of science and business journalism. Now he returns to tell the story of Vertex's bold endurance and eventual success. The pharmaceutical business is America's toughest and one of its most profitable. It's riskier and more rigorous at just about every stage than any other business, from the towering biological uncertainties inherent in its mission to treat disease; to the 30-to-1 failure rate in bringing out a successful medicine; to the multibillion-dollar cost of ramping up a successful product; to operating in the world's most regulated industry, matched only by nuclear power. Werth captures the full scope of Vertex's 25-year drive to deliver breakthrough medicines.--From publisher description.
Damages is the riveting true story of one family’s legal struggles in the world of medicine. At the urging of a friend, the Sabias filed a medical malpractice lawsuit against Dr. Humes and Norwalk Hospital. Barry Werth takes us through the seven-year lawsuit, allowing us to see the legal strategy plotted by the Sabias’s attorneys, Connecticut’s premier medical malpractice law firm.
In 1989, the charismatic Joshua Boger left Merck, then America's most admired business, to found a drug company that would challenge industry giants and transform health care. Journalist Barry Werth described the company's tumultuous early days during the AIDS crisis in The Billion-Dollar Molecule, a celebrated classic of science and business journalism. Now he returns to tell the story of Vertex's bold endurance and eventual success. The pharmaceutical business is America's toughest and one of its most profitable. It's riskier and more rigorous at just about every stage than any other business, from the towering biological uncertainties inherent in its mission to treat disease; to the 30-to-1 failure rate in bringing out a successful medicine; to the multibillion-dollar cost of ramping up a successful product; to operating in the world's most regulated industry, matched only by nuclear power. Werth captures the full scope of Vertex's 25-year drive to deliver breakthrough medicines.--From publisher description.
During his thirty-seven years at Smith College, Newton Arvin published groundbreaking studies of Hawthorne, Whitman, Melville, and Longfellow that stand today as models of scholarship and psychological acuity. He cultivated friendships with the likes of Edmund Wilson and Lillian Hellman and became mentor to Truman Capote. A social radical and closeted homosexual, the circumspect Arvin nevertheless survived McCarthyism. But in September 1960 his apartment was raided, and his cache of beefcake erotica was confiscated, plunging him into confusion and despair and provoking his panicked betrayal of several friends. An utterly absorbing chronicle, The Scarlet Professor deftly captures the essence of a conflicted man and offers a provocative and unsettling look at American moral fanaticism.
"Damages" is a riveting true story of one negligence suit, pitting doctors against lawyers in the medical malpractice case of a profoundly handicapped child--and exposing the pain and courage of a family swept up in both. A fascinating exploration of what happens when the legal and medical worlds collide.
In 31 Days, acclaimed historian Barry Werth takes readers inside the White House during the tumultuous days of August 1974, following Richard Nixon's resignation and the swearing-in of America's "accidental president," Gerald Ford. The Watergate scandal had torn the country apart. In a dramatic, day-by-day account of the new administration’s inner workings, Werth shows how Ford, caught between political expedience, the country’s demands for justice, and his own moral compass, struggled valiantly to restore the nation’s tarnished faith in its leadership. With deft and refreshing analysis Werth illuminates how this unprecedented political upheaval produced new fissures and battle lines, as well as new opportunities for political advancement for ambitious young men such as Donald Rumsfeld, who had been Nixon’s ambassador to NATO, and Dick Cheney, already coolly efficient as Rumsfeld’s former deputy. A superbly crafted presidential history with all of the twists and turns of a thriller, 31 Days sheds new light on the key players and political dilemmas that reverberate in today’s headlines.
A grand and sweeping history of ideas, "Banquet at Delmonico's" tells the intimate and dramatic story of how Charles Darwin, Herbert Spencer, and a group of influential American allies together made evolution the guiding spirit of the Gilded Age.
As a child grows and develops inside its mother's womb, parents constantly ask each other 'What's happening with the baby now'?' As a result of Alexander Tsiaras' s remarkable achievements in medical imaging technology, they can turn to the pages of this extraordinary book for an answer at any point during the pregnancy -from conception to birth.FROM CONCEPTION TO BIRTH is based on hvo revolutions in science. As biologists have decoded the molecular basis of life, computer scientists have developed three-dimensional techniques for scanning and displaying the body; which can isolate nervous, skeletal, circulatory systems and view them down to a molecular level. Alexander Tsiaras founded his m...
Yaddo is a rich account of America's premier artists' retreat, which has hosted some of the twentieth century's most renowned writers, composers, and visual artists. Hannah Arendt, James Baldwin, Saul Bellow, Leonard Bernstein, Elizabeth Bishop, Truman Capote, Flannery O'Connor, Aaron Copland, Langston Hughes, Carson McCullers, Sylvia Plath, Philip Roth, Clyfford Still, and William Carlos Williams all lived and worked at Yaddo. Richly illustrated with photographs, prints, intimate letters, papers, and ephemera from archives and collections at both Yaddo and TheNew York Public Library, this collection provides a window into the famously private institution, recounting the experiences of the artists who took advantage of a bucolic retreat to tap into--and mingle with--genius. With essays by Marcelle Clements, David Gates, Allan Gurganus, Tim Page, Ruth Price, Barry Werth, Karl Emil Willers, and Helen Vendler, and an overview by curator Micki McGee, Yaddo is a collaborative project that revisits the major moments of twentieth-century American culture and history.