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Do individuals have an economic personality? Is there a model for real-life human economic behavior? Can real-life economic behaviors be predicted? This book identifies the theory of economic personality. Economic personality leads an individual to exhibit predictable behaviors without the need to be rational in cases of uncertainty. So, this book argues that the individual is not rational; what is rational, however, is the systematic repetition of behaviors dictated by people's economic personalities.
This book focuses on the new discipline of translational medicine as it pertains to drug development within the pharmaceutical and biotechnology industry. It is essential for anyone interested in translational medicine from a variety of backgrounds: university institutes, medical schools, pharmaceutical companies and drug development researchers and decision-makers.
This book is a venture in the worlds of modeling and of metamodeling. At this point, I will not reveal to readers what constitutes metamodeling. Suf fice it to say that the pitfalls and shortcomings of modeling can be cured only if we resort to a higher level of inquiry called metainquiry and metadesign. We reach this level by the process of abstraction. The book contains five chapters from my previous work, Applied General Systems Theory (Harper and Row, London and New York, First Edition 1974, Second Edition 1978). More than ten years after its publication, this material still appears relevant to the main thrust of system design. This book is dedicated to all those who are involved in chan...
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Since 1945, socially moderated market economies have formed the cornerstone of the European socioeconomic model. Now, however due to powerful global economic, political and demographic tendencies tensions between social and economic interests and values are increasing. These developments create an urgent need for answers, actions and measures on the European level. This wide-ranging but focused collection of essays approaches this important trend from multiple perspectives. Compiled in honour of the major European labour law scholar Teun Jaspers, it encompasses a broad spectrum of analyses and insights by forty-one distinguished contributors from seven countries. Four major tensions are iden...
This volume focuses on various aspects of interleukin-27 (IL-27), especially its potential for clinical applications. The authors discuss the downstream signaling from the IL-27 receptor and its molecular targets in immune cells including Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells by IL-27 is vital for the maintenance of the feto-maternal tolerance and the prevention of lupus, multiple sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis. However, the same inhibitory capabilities compromise the immune response to bacterial pathogens, and IL-27 is a pathogenic factor in sepsis and tuberculosis. Also covered are the conflicting reports on the role of IL-27 in rheumatoid arthritis, the effect of IL-27 on epithelia, which seems to play a role in asthma, psoriasis and inflammatory bowel diseases, and the direct cytotoxic and anti-vascular effects of IL-27, which make it a promising agent for the treatment of cancer. Accordingly, this volume will be of interest to researchers and clinicians alike.
This is an open access title available under the terms of a [CC BY-NC-ND 4.0 International] licence. It is free to read on the Oxford Academic platform and offered as a free PDF download from OUP and selected open access locations. Herbert Simon held that the fundamental turn in the study of bounded rationality is the turn from substantive to procedural rationality. Theories of substantive rationality begin with normative questions about attitudes: what should we prefer, intend, or believe? By contrast, theories of procedural rationality begin with normative questions about processes of inquiry: how should we determine what to prefer, intend, or believe? If Simon was right, then the central ...
In this Handbook of Experimental Pharmacology on “High Density Lipoproteins – from biological understanding to clinical exploitation” contributing authors (members of COST Action BM0904/HDLnet) summarize in more than 20 chapters our current knowledge on the structure, function, metabolism and regulation of HDL in health and several diseases as well as the status of past and ongoing attempts of therapeutic exploitation. The book is of interest to researchers in academia and industry focusing on lipoprotein metabolism, cardiovascular diseases and immunology as well as clinical pharmacologists, cardiologists, diabetologists, nephrologists and other clinicians interested in metabolic or inflammatory diseases.
This concise and insightful book studies the role of the ISDS mechanism in the legalization, and legitimacy, of the international investment law regime. Providing an interdisciplinary perspective on ISDS through the constructivist theory of international relations, this book argues that reforming ISDS can contribute to the legalization of international investment law, but such a contribution is subject to both “institutional” and “internal” limitations.
Dyslipidemias: Pathophysiology, Evaluation and Management provides a wealth of general and detailed guidelines for the clinical evaluation and management of lipid disorders in adults and children. Covering the full range of common through rare lipid disorders, this timely resource offers targeted, practical information for all clinicians who care for patients with dyslipidemias, including general internists, pediatric and adult endocrinologists, pediatricians, lipidologists, cardiologists, internists, and geneticists. For the last twenty years, there has been a growing recognition worldwide of the importance of managing dyslipidemia for the primary and secondary prevention of atherosclerotic...