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The book highlights important new research using current state-of-the-art approaches by prominent researchers in the field of depression. A broad range of topics is covered, beginning with a description of the phenotypic features of clinical depression, followed by chapters on the cellular and molecular basis, functional neuroimaging correlates and information-processing accounts. Finally, existing and novel treatment approaches are covered. In this way the volume brings together the key disciplines involved in the neurobiological understanding of depression to provide an update of the field and outlook to the future. Together, the volume chapters provide focused and critical reviews that span a broad range of topics suitable for both students and established investigators interested in the present state of depression research.
Life has been good for Justin Nelson. With a big bowl game mere weeks away, the pressure is on. For some men, being stretched in two different directions might become too much, but not for Justin, he thrives on it. Trying to balance life with his long-time partner, Luc, and his duty to the team gives Justin a rush like no other. Luc Henley hates seeing the love of his life push himself. Every football season it seems to get worse as he watches Justin burn the candle at both ends. When he notices warning signs of a potential health problem, Luc begs Justin to slow down enough to see a doctor. After he ignores his lover's pleas, Justin is suddenly faced with a life-changing illness, and when he gives up, it's up to Luc, Justin's friends and players to pull him back from the brink of despair.
The first “devilishly good” (The New York Times Book Review) book in the thrilling bestselling crime series featuring British inspector Alan Banks as he seeks to catch a Jack the Ripper-like killer who is prowling the countryside. Chief Inspector Alan Banks moved away from London to the quaint village of Eastvale to find some peace, but trouble can be found in a village as well as in the city. Soon Banks must contend with a Peeping Tom, a group of thieving young thugs, and the brutal murder of an elderly woman in her home. A growing friendship with psychologist Jenny Fuller and tension with wife Sandra complicate matters, particularly when Jenny and Banks’s family are threatened. Ultimately, as the story builds to a surprising and terrifying climax, Banks must make some hard decisions.
Physical and emotional scars drove Jonah to a life in the shadows, but Trevor is determined to draw him out of the dark and into his arms. After spending months in a military rehabilitation hospital, Jonah returns from active duty only to find himself homeless. Jonah retreats to life in the shadows to hide his facial scars. He takes up residence in the parking garage of The Melia Hotel where he watches a striking black man come and go from his work inside the hotel. What Jonah doesn't know is that General Manager Trevor Sharp is also watching him. Trevor spends his days and most of his evenings at the Melia, working hard to prove he is the best man for the job. Unfortunately, between his hours and past heartbreaks, he doesn't have much time for love. When a handsome man comes out of nowhere to save him from an abusive ex, Trevor makes it his mission to find out who the man is. Trevor eventually builds a friendship with Jonah and works to draw him out of the shadows and into his arms, but will he stay there?
Serotonin (5-hydroxytryptamine, often cited as 5-HT) is one of the major excitatory neurotransmitter, and the serotonergic system is one of the best studied and understood transmitter systems. It is crucially involved in the organization of virtually all behaviours and in the regulation of emotion and mood. Alterations in the serotonergic system, induced by e.g. learning or pathological processes, underlie behavioural plasticity and changes in mood, which can finally results in abnormal behaviour and psychiatric conditions. Not surprisingly, the serotonergic system and its functional components appear to be targets for a multitude of pharmacological treatments - examples of very successful d...
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Microdialysis is currently one of the most important in vivo sampling methods in physiology and pharmacology. It is used to determine the chemical components of the fluid in the extracellular space of tissues. The technique is now well established in neuroscience research and is used excessively in behavioral neuroscience to determine the concentrations and identities of molecules in brain tissues, and their change due to behavior, hormonal and transmitter changes in the nervous system. The book provides a detailed comprehensive overview of the technology and its applications, including application in pathology, drug development, and the application in the clinic. The authors are all well kn...