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Radiation-induced effects and the immune system
Numerous developments in molecular biology have led to an explosive growth in the knowledge underlying mechanisms of carcinogenesis, cell signalling, tumor progression and development of metastasis. However, cure of cancer is still hampered by the inherited capacity of tumors to become resistant to standard therapies, to metastasize from their initial location and to proliferate in other tissue compartments. Radiotherapy is one of the main treatment modalities to achieve locoregional tumor control. However, the treatment of distant metastases further remains to be a challenge. In this special topic we are interested to elucidate immunological aspects which are initiated and affected by radio...
Radiation and the Immune System: Current Knowledge and Future Perspectives
For long, high dose ionizing radiation was considered as a net immune suppressing agent, as shown, among others, by the exquisite radiosensitivity of the lymphoid system to radiation-induced cell killing. However, recent advances in radiobiology and immunology have made this picture more complex. For example, the recognition that radiation-induced bystander effects, share common mediators with various immunological signalling processes, suggests that they are at least partly immune mediated. Another milestone was the finding, in the field of onco-immunology, that local tumor irradiation can modulate the immunogenicity of tumor cells and the anti-tumor immune responsiveness both locally, in t...
Cell Death in Cancer Immunology
The relationship between cell death and cancer immunology has been addressed for decades with different approaches because cell death has an immunomodulatory activity involved in the origin, progression and metastasis of tumors. Specifically, efforts have been devoted to: 1) ascertaining the role of the immune system in the resistance to cell death by tumor cells, 2) discerning how, paradoxically, cell death can lead to immunosuppression that favors tumor progression, 3) explaining the mechanisms by which cell death induces tumor immunogenicity, 4) studying how dead, or dying, tumor cells exert an immunomodulatory effect on their tumor microenvironment, 5) investigating how tumor cell death is induced by different types of immunotherapy.
Osteoarticular-immunological Interplay in Response to Disease and Therapy
Dr. Tomcik receives research funding from Arxx Therapeutics. The other Topic Editors declare no competing interests.
Community Series in Novel Biomarkers for Predicting Response to Cancer Immunotherapy, volume II
This Research Topic is the second volume of the “Community Series in Novel Biomarkers for Predicting Response to Cancer Immunotherapy". Please see Volume I here. Immunotherapy has revolutionized the treatment of malignancies. Targeting of immune checkpoints cytotoxic T-lymphocyte-associated protein 4, programmed cell death protein 1 (PD-1) and its ligand (PD-L1) has led to improving survival in a subset of patients. Despite their remarkable success, clinical benefit remains limited to only a subset of patients. A significant limitation behind these current treatment modalities is an irregularity in clinical response, which is especially pronounced among checkpoint inhibition. Currently, re...
