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Radiation-induced effects and the immune system
  • Language: en
  • Pages: 131

Radiation-induced effects and the immune system

Numerous developments in molecular biology have led to an explosive growth in the knowledge underlying mechanisms of carcinogenesis, cell signalling, tumor progression and development of metastasis. However, cure of cancer is still hampered by the inherited capacity of tumors to become resistant to standard therapies, to metastasize from their initial location and to proliferate in other tissue compartments. Radiotherapy is one of the main treatment modalities to achieve locoregional tumor control. However, the treatment of distant metastases further remains to be a challenge. In this special topic we are interested to elucidate immunological aspects which are initiated and affected by radio...

Radiation and the Immune System: Current Knowledge and Future Perspectives
  • Language: en
  • Pages: 283

Radiation and the Immune System: Current Knowledge and Future Perspectives

For long, high dose ionizing radiation was considered as a net immune suppressing agent, as shown, among others, by the exquisite radiosensitivity of the lymphoid system to radiation-induced cell killing. However, recent advances in radiobiology and immunology have made this picture more complex. For example, the recognition that radiation-induced bystander effects, share common mediators with various immunological signalling processes, suggests that they are at least partly immune mediated. Another milestone was the finding, in the field of onco-immunology, that local tumor irradiation can modulate the immunogenicity of tumor cells and the anti-tumor immune responsiveness both locally, in t...

Radioimmunotherapy – Translational Opportunities and Challenges
  • Language: en
  • Pages: 144
Osteoarticular-immunological Interplay in Response to Disease and Therapy
  • Language: en
  • Pages: 115

Osteoarticular-immunological Interplay in Response to Disease and Therapy

Dr. Tomcik receives research funding from Arxx Therapeutics. The other Topic Editors declare no competing interests.

Immune Checkpoint Biology in Health and Disease
  • Language: en
  • Pages: 310

Immune Checkpoint Biology in Health and Disease

  • Type: Book
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  • Published: 2024-01-15
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  • Publisher: Elsevier

Immune Checkpoint Biology in Health and Disease, Volume 382 provides in-depth reviews on the latest progress concerning research on immune-checkpoint biology and its immunotherapeutic implications, especially in cancer. Topics connected to immune-checkpoint biology covered in this volume include Novel technologies for applying immune checkpoint blockers, Next-generation deconvolution of transcriptomic data to investigate the tumor microenvironment, Immune checkpoints targeting dendritic cells for antibody-based modulation in cancer, Immune checkpoint biology in health & disease: Immune checkpoint biology and autoimmunity in cancer patients, and much more.Other sections cover Recent advanceme...

Immune-Related Adverse Events for Patients with Lung Cancer
  • Language: en
  • Pages: 180

Immune-Related Adverse Events for Patients with Lung Cancer

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Targeting DNA damage response to enhance antitumor innate immunity in radiotherapy
  • Language: en
  • Pages: 155