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Space Biology and Medicine: Humans in spaceflight (bks. 1 & 2)
Nicogossian, Arnauld E., Investigator, NASA Center: HQS.
Announcements
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Spacefaring
Publisher Fact Sheet An exploration of the human side of spaceflight: what living & working in space will really be like in the decades to come.
DHEW Publication
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Inactivity: Physiological Effects
Inactivity: Physiological Effects describes the physiological deconditioning inherent in inactivity and immobilization. This book is organized into eight chapters that review the body of information from studies on healthy volunteers conducted in direct support of the space program. Considerable chapters are devoted to the changes occurring in the cardiovascular system, bone and muscle, metabolism and endocrine responses, psychosocial responses, and exercise tolerance. Other chapters discuss the clinical effects and clinical management of deterioration while indicating the changes that have been found in health, normal bed rested subjects. The remaining chapters explore the data on crews that have flown in since their physiological responses are qualitatively similar to those observed in bed rested subjects or immobilized patients on earth. Clinicians, nursing staff, physiologists, researchers, and students in the field will find this book invaluable.
A Strategy for Research in Space Biology and Medicine in the New Century
Construction of the international space station, scheduled to start in late 1998, ushers in a new era for laboratory sciences in space. This is especially true for space life sciences, which include not only the use of low gravity as an experimental parameter to study fundamental biological processes but also the study of the serious physiological changes that occur in astronauts as they remain in space for increasingly longer missions. This book addresses both of these aspects and provides a comprehensive review of ground-based and space research in eleven disciplines, ranging from bone physiology to plant biology. It also offers detailed, prioritized recommendations for research during the next decade, which are expected to have a considerable impact on the direction of NASA's research program. The volume is also a valuable reference tool for space and life scientists.
Bone-Metabolic Functions and Modulators
Recent research, which Bone- Metabolic Function and Modulators expands on, has added new support to the idea that bone not only serves as a support system, but also functions as an integrating organ, with a significant regulatory role for lipid and energy metabolism. Links between physical activity and the skeleton are also becoming increasingly clear. This fully illustrated volume contains up-to-date information on the metabolic role of the skeleton and what this can mean for the treatment of metabolic as well as skeletal and auditory diseases. Bone- Metabolic Function and Modulators is of particular interest to clinician scientists, clinical and basic bone researchers, orthopedists, endocr...
Small Clinical Trials
Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharma...
