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Hormone Signaling
Multicellular organisms require a means of intracellular communication to organize and develop the complex body plan that occurs during embryogenesis and then for cell and organ systems to access and respond to an ever changing environmental milieu. Mediators of this constant exchange of information are growth factors, neurotransmmitters, peptide and protein hormones which bind to cell surface receptors and transduce their signals from the extracellular space to the intracellular compartment. Via multiple signaling pathways, receptors of this general class affect growth, development and differentiation. Smaller hydrophobic signaling molecules, such as steroids and non-steroid hormones, vitamins and metabolic mediators interact with a large family of nuclear receptors. These receptors function as transcription factors affecting gene expression, to regulate the multiple aspects of animal and human physiology, including development, reproduction and homeostasis. The aim of this book is to cover various aspects of intracellular signaling involving hormone receptors.
Insights into Infertility Management
This new edition is a complete guide to infertility management for specialists in reproductive medicine and trainees. Divided into 28 chapters, the book begins with an overview of the prevalence of infertility, female endocrinology and male infertility. The following sections cover the diagnosis of different causes of infertility and the various assisted reproductive techniques (ART) available. Separate chapters discuss fertility preservation in gynaecologic cancer patients, and laboratory set up for IVF. The second edition has been fully revised and new topics added to provide the latest advances in the field. The comprehensive text is further enhanced by more than 200 clinical photographs, diagrams and tables. Key points Complete guide to infertility management for clinicians and trainees Fully revised second edition with new topics included Features more than 200 clinical photographs, diagrams and tables Previous edition (9789350255186) published in 2011
Ion Pumps, Part A
Both eukaryotic and prokaryotic cells depend strongly on the function of ion pumps present in their membranes. The term ion pump, synonymous with active ion-transport system, refers to a membrane-associated protein that translocates ions uphill against an electrochemical potential gradient. Primary ion pumps utilize energy derived from chemical reactions or from the absorption of light, while secondary ion pumps derive the energy for uphill movement of one ionic species from the downhill movement of another species. In the present volume, various aspects of ion pump structure, mechanism, and regulation are treated using mostly the ion-transporting ATPases as examples. One chapter has been devoted to a secondary ion pump, the Na+-Ca2+ exchanger, not only because of the vital role played by this transport system in regulation of cardiac contractility, but also because it exemplifies the interesting mechanistic and structural similarities between primary and secondary pumps.
Advances in Molecular and Cellular Endocrinology
Volume 2 has focused on aspects of the pituitary gland both anterior (growth hormone and prolactin receptors, and GH action) and posterior (vasopressin) pituitary. In addition, thyroid cancer and steroidogenic enzymes and precocious puberty are covered. Finally, the "hot topics" include leptin and growth factor signaling.
Constitutive Activity in Receptors and Other Proteins, Part A
This volume of Methods in Enzymology covers the current methodology for the detection and assessment of constitutively active proteins. The chapters written by expert authors who are leaders in the field, provide hints and tricks not available in primary research publications.It is extensively referenced, with useful figures and tables throughout the volume. Expert authors who are leaders in the field Extensively referenced and useful figures and tables Provides hints and tricks to facilitate reproduction of methods
Binary Stars, Neutrinos, and Liquid Crystals:
This book traces the parallel paths of physics and astronomy at the University of Pennsylvania, starting with their genesis in the 18th century, through the rising stature of both departments in the 20th century, and concluding with their unification in 1994. Along the way we meet David Rittenhouse, who observed the transit of Venus in 1769, Charles Doolittle, whose remarkable beard would freeze to his telescope on cold nights, Gaylord Harnwell, who transformed first the physics department and then the entire university, and Raymond Davis, who uncovered a mystery in the middle of the sun. The stories are tragic (Arthur Goodspeed failed to discover X-rays through inattention), horrifying (Dicran Kabakjian poisoned an entire neighborhood), and celebratory (three Penn physicists received the Nobel Prize in the late 20th Century). The reader will gain an appreciation, not just of the history of one institution, but of the ways these two disciplines both intersect and complement each other.
Text, Speech and Dialogue
This volume contains the Proceedings of the 7th International Conference on Text, Speech and Dialogue, held in Brno, Czech Republic, in September 2004, under the auspices of the Masaryk University. This series of international conferences on text, speech and dialogue has come to c- stitute a major forum for presentation and discussion, not only of the latest developments in academic research in these ?elds, but also of practical and industrial applications. Uniquely, these conferences bring together researchers from a very wide area, both intellectually and geographically, including scientists working in speech technology, dialogue systems, text processing, lexicography, and other related ?e...
Toward a Theory of Neuroplasticity
This book provides a broad survey of many of the major areas in neuroplasticity research by leading investigators in the field. The topics considered range across all levels of nervous system organization from the molecular to behavioral levels for species ranging from C. elegans to humans. In addition, the effects of development and neuropathological events are discussed. A final summary chapter synthesizes the data gathered in this volume in order to provide the basis for a general theory of neuroplasticity.
