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Progress in Chemokine Research
Chemokines are the cytokines that may activate or chemoattract leukocytes. Each chemokine contains 65 ~ 120 amino acids, with molecular weight of 8-10 kD. Their receptors belong to G-protein-coupled receptors. Inflammatory chemokines are released from a wide variety of cells in response to bacterial infection, viruses and agents that cause physical damage such as silica or the urate crystals that occur in gout. They function mainly as chemoattractants for leukocytes, recruiting monocytes, neutrophils and other effector cells from the blood to sites of infection or damage. They can be released by many different cell types and serve to guide cells involved in innate immunity and also the lymphocytes of the adaptive immune system. The cells that are attracted by chemokines follow a signal of increasing chemokine concentration to the site of infection or tissue injury. Some chemokines also have roles in the development of lymphocytes, migration and angiogenesis (the growth of new blood vessels).Since the entry of HIV into host cells requires chemokine receptors, their antagonists are being developed to treat AIDS. This book presents leading research from around the globe in this field.
The Murder on the Links
The Murder on the Links by Agatha Christie - is a work of detective fiction by Agatha Christie, first published in the US by Dodd, Mead amp; Co in March 1923, and in the UK by The Bodley Head in May of the same year. It is the second novel featuring Hercule Poirot and Arthur Hastings. The UK edition retailed at seven shillings and sixpence (7/6), and the US edition at $1.75. The story takes place in northern France, giving Poirot a hostile competitor from the Paris Sûreté. Poirot's long memory for past or similar crimes proves useful in resolving the crimes. The book is notable for a subplot in which Hastings falls in love, a development "greatly desired on Agatha's part... parcelling off ...
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Rudolf Schiestl
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