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Connecting the Dots Between Inflammation and the Inner Workings of Programmed Cell Death
Programmed cell death (PCD) is central in maintaining the life of multicellular organisms, during development as well as in healthy adulthood or in the context of disease. The best understood form of PCD is apoptosis, a caspase mediated, immunologically silent cell death that can be initiated in probably all cell types upon aging, lack of growth support, critical damage or infection. One of the key pathways of apoptosis involves mitochondrial outer membrane permeabilization (MOMP), a process tightly regulated by members of the BCL-2 family. Whereas PCD and apoptosis were used synonymously in the past, other forms of PCD have been discovered more recently, including RIPK1/3- and MLKL-dependen...
Apoptotic and Non-apoptotic Cell Death
This volume focuses on apoptotic and non-apoptotic programmed cell death, including necroptosis, pyroptosis, and ferroptosis, and presents recent findings in the field. It discusses the crucial role that apoptotic and non-apoptotic cell death play in various pathological conditions, such as skin diseases, inflammatory bowel diseases, and virus infections. Further, it highlights the mechanisms underlying the recognition and clearance of dead cells, and the subsequent biological responses triggered by phagocytosed macrophages and factors released from dying cells. Offering insights into cell death, it is a valuable resource for researchers and clinicians developing novel strategies to treat various diseases that are closely associated with cell death.
Evidence Based Dermatology
Evidence-based thinking in clinical medicine has impacted greatly on the physician's approach to clinical care. Evidence-Based Dermatology introduces and encourages the concept of evidence-based patient care in dermatology. Incorporating a text that is much more than merely the summary of trial data, the authors worked to explore disease mechanisms and treatments in greater depth and detail in order to provide more insight for the reader. In addition to promoting the understanding of the evidence-based philosophy, the authors have focused on some of the fundamentals in dermatology that need to be approached differently. Issues such as the interpretation of clinical research, disease-oriented evidence versus patient-care evidence, and the use of placebo are examined.
The Journal of Cell Biology
No. 2, pt. 2 of November issue each year from v. 19 (1963)-47 (1970) and v. 55 (1972)- contain the Abstracts of papers presented at the Annual Meeting of the American Society for Cell Biology, 3d (1963)-10th (1970) and 12th (1972)-
Inflammasome Biology
Inflammasome Biology: Fundamentals, Role in Disease States, and Therapeutic Opportunities is a complete reference on the role of inflammasomes in health and disease. Sections cover the different types of inflammasomes, including cellular signaling, structural and evolutive aspects, overview the role of inflammasomes in key diseases, microbial infections and human body systems conditions, cover the interplay between Inflammasomes and cell death processes, and discuss current therapeutic opportunities driven by inflammasome research, including targeting, blocking and inhibiting the development of inflammasomes through both synthetic and natural compounds. This book is the perfect reference for cell biologists, immunologists and research clinicians to understand the foundations of inflammasomes and explore the therapeutic opportunities they present. Pharma researchers may also find this reference invaluable in devising new approaches to developing anti-inflammatory drugs. - Provides comprehensive coverage of the subject of inflammasome biology - Authored by leading experts worldwide - Provides biological insights that have both health implications and therapeutic potential
Crosstalk between Cell Death, Oxidative Stress, and Immune Regulation
Cell death, a biological event important for maintaining the growth, development, and life processes of organisms, mainly includes programmed death (apoptosis, pyroptosis, autophagy, mitochondrial apoptosis, ferroptosis, cuproptosis, and disulfidptosis, etc.) and non-programmed death (cell necrosis). Many diseases, including cancers, exhibit dysregulated immune activities as key features due to the increase in oxidative stress, which eventually leads to cell death. Understanding the intricate relationships between cell death, oxidative stress, and immune regulation could be critical in elucidating the key molecular mechanisms of these diseases, possibly uncovering novel therapeutics/diagnostics for disease management. For example, ferroptosis, a form of iron-dependent cell death that is triggered by the toxic accumulation of oxidative stress, can induce immunosuppression in tumor neutrophils, whereas inhibition of ferroptosis can slow tumor progression. For another example, pyroptosis, a form of lytic cell death which can be triggered by oxidative stress, when occurs in tumor cells, can induce a strong inflammatory response and significant tumor regression.
Anticancer Research
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