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The Diabetic Pancreas
Since the publication of the first edition of The Diabetic Pancreas in 1977, much progress has been made in various areas of diabetes research. While only a rela tively short while ago diabetes was considered a single disease, in more recent years it has become apparent that it is a heterogeneous group of disorders, all of which are characterized by a decreased tolerance of carbohydrates and most of which have a genetic basis, although the genetic types vary. In more recent years, an International Work Group sponsored by the National Diabetes Data Group of the NIH proposed a now generally accepted classification, according to which the insulin-dependent ketosis-prone diabetes, formerly and i...
Pioneers in Neuroendocrinology
In the middle and late 1960s, when it was clear that neuroendocrinology was established as a discipline in its own right, it occurred to us that auto biographical accounts of the pioneer work in this field by the major par ticipants would provide a highly interesting and informative account of his tory in the making. With the death of G. W. Harris in late 1971, and the loss thereby of an outstanding pioneer and personality in neuroendocri nology, it appeared to us to be even more urgent to undertake such a ven ture and collect as many stories as possible. The three of us agreed that initially we would limit our invitations to the senior investigators whose re search careers lay mostly behind...
Endocrine Pathology of the Gut and Pancreas
This important new book presents critical information on the clinical and morphological aspects of various endocrinological disorders of the gut and pancreas. Topics include a historical perspective and broad overview of the neuroendocrine component of the gut; hyperplastic proliferations of gastrointestinal endocrine cells; pancreatic endocrine cells and their non-neoplastic proliferations; tumors and lesions; and endocrine differentiation in nonendocrine tumors. The book stresses clinical and pathological aspects of these topics, as well as the pathogenesis, clinicopathological correlations, and diagnostic approaches. Gastroenterologists, pathologists, internists, surgeons, endocrinologists and others interested in endocrinological disorders of the gut and pancreas will discover that this book will be a welcome addition to your reference library.
The Insulinotropic Gut Hormone Glucagon-like Peptide-1
Glucagon-like peptide-1 (GLP-1) is a promising new therapeutic tool for the treatment of diabetes. Since the first reports describing its potent insulinotropic activity were published about a decade ago, knowledge of the incretin hormones, and GLP-1 in particular, has increased significantly. This timely volume summarizes what is now known about the molecular biology, physiology and pharmacology of GLP-1. Thorough coverage is given to the physiology of the hormone, including its generation, release and actions at pancreatic and extrapancreatic tissues. The intracellular mechanisms of GLP-1 are also described in detail. Discussion of the molecular biology includes the structure and functions of the genes coding for proglucagon and the GLP-1 receptor. A special feature of the book is the clinical information provided which includes data on the expression and release of GLP-1 and its potential use as a therapeutic agent for diabetes. Presenting the results of exciting new research, this book will be a valuable reference for endocrinologists, gastroenterologists, pharmacologists, physiologists and biochemists interested in this important hormone.
Partnership for Excellence
In Partnership for Excellence, senior medical historian and award-winning author Edward Shorter details the Faculty of Medicine's history from its inception as a small provincial school to its present day status as an international powerhouse.
Personal Names, Hitler, and the Holocaust
Personal Names, Hitler, and the Holocaust: A Socio-Onomastic Study of Genocide and Nazi Germany provides readers with an increased understanding of and sensitivity to the many powerful ways in which personal names are used by both perpetrators and victims during wartime. This book concentrates on one of the most terrifying and yet fascinating periods of modern history: the Holocaust. In particular, it examines the different ways in which personal names were used by Nationalist Socialists to hunt and destroy the victims of their genocidal ideology. Even before requiring Jewish residents to wear a yellow Star of David and have the letter “J” stamped on their passports, Nazi leaders had dec...
The Peptidergic Neuron
Neuropeptides rank among the phylogenetically oldest interneuronal signal substances. In the concept of neuro-secretion they were identified as neurohormones by which - via the blood - the brain regulates peripheral functions. It is now evident that the neuropeptides act as neurotransmitters/-modulators, as (neuro-)hormones, and paracrine or autocrine signal substances in diverse parts of the body. This book reviews, in several comprehensive articles written by distinguished specialists, the state of the art in the field of neuropeptides and peptidergic neurons. Special topics concern molecular aspects of processing, release and degradation of neuropeptides, receptors and signal transduction, comparative and behavioural aspects, and immunoregulatory effects of neuropeptides and their involvement on pathology of the central nervous system.
Somatostatin
The discovery of hypothalamic factors that inhibited growth hormone secretion and of pancreatic factors that inhibited insulin secretion were the first clues to the existence of somatostatin. During the course of efforts to isolate growth hormone releasing factor, Krulich, McCann and Dhariwal found that hypothalamic extracts contained a potent inhibitor of growth hormone secretion. They postulated that growth hormone secretion was under a dual control system, one inhibitory and the other excitatory (I) . In studies being carried out at about the same time, Hellman and Lernmark found a factor in pancreatic extracts that inhibited insulin secretion (2). They postulated that islet cell function...
Margaret and Charley
More than just the story of Charles Bests discovery of insulin, this is the tale of an extraordinary couple, told through diaries, scrapbooks, and photographs.
Neurological Eponyms
Eponyms and biographical information are included in these areas of neurology: diagnosis, signs, symptoms, tests, reflexes, syndromes, diseases, and defects.
